The epithelial sodium channel (ENaC) is composed of three homologous subunits and
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disorder characterized
by progressive replacement of cardiomyocytes by fibrofatty tissue, ventricular dilatation …

Abstract The epithelial Na+ channel (ENaC) emerged early in vertebrates and has played a
role in Na+ and fluid homeostasis throughout vertebrate evolution. We previously showed …

The epithelial Na+ channel (ENaC) has a key role in the regulation of extracellular fluid
volume and blood pressure. ENaC belongs to a family of ion channels that sense the …

Epithelial Na+ channels (ENaCs) and related channels have large extracellular domains
where specific factors interact and induce conformational changes, leading to altered …

The epithelial Na+ channel (ENaC) functions as a pathway for Na+ absorption in the kidney
and lung, where it is crucial for Na+ homeostasis and blood pressure regulation. However …

Pendrin is a Na+-independent Cl−/HCO3− exchanger found in the apical regions of type B
and non-A, non-B intercalated cells within the aldosterone-sensitive region of the nephron …

The epithelial sodium channel (ENaC) is a critical regulator of vertebrate electrolyte
homeostasis. ENaC is the only constitutively open ion channel in the degenerin/ENaC …

The epithelial Na+ channel (ENaC)/degenerin family has a similar extracellular architecture,
where specific regulatory factors interact and alter channel gating behavior. The …

Neuronal PAS domain protein 2 (NPAS2) is a core clock transcription factor that forms a
heterodimer with BMAL1 to bind the E-box in the promoter of clock genes and is regulated …