[HTML][HTML] Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose …
M Verheijen, Y Schrooders, H Gmuender, R Nudischer… - Toxicology letters, 2018 - Elsevier
Doxorubicin (DOX) is a chemotherapeutic agent of which the medical use is limited due to
cardiotoxicity. While acute cardiotoxicity is reversible, chronic cardiotoxicity is persistent or …
cardiotoxicity. While acute cardiotoxicity is reversible, chronic cardiotoxicity is persistent or …
[HTML][HTML] Prediction of the human pharmacokinetics of epyrifenacil and its major metabolite, S-3100-CA, by a physiologically based pharmacokinetic modeling using …
K Hirasawa, J Abe, H Nagahori, S Kitamoto - Toxicology and Applied …, 2022 - Elsevier
Human internal dosimetry of pesticides is essential in the risk assessment when toxicity has
been confirmed in laboratory animals. While human toxicokinetics data of pesticides are …
been confirmed in laboratory animals. While human toxicokinetics data of pesticides are …
Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen …
C Zhang, Q Zhang, J Li, L Yu, F Li, W Li, Y Li… - Regulatory Toxicology …, 2020 - Elsevier
Selection of appropriate fit-for-purpose in vitro and in silico models is critical for non-animal
safety assessment of chemical-induced hepatoxicity. The present study evaluated the …
safety assessment of chemical-induced hepatoxicity. The present study evaluated the …
Pharmacokinetic Prediction of Immediate-and Extended-Release Tablets for Patients with Liver Disease Using Whole Body Physiologically-Based Pharmacokinetic …
JH Jang, SH Jeong - AAPS PharmSciTech, 2025 - Springer
Although quetiapine metabolism occurs extensively in the liver and careful dosing is
recommended in patients with liver disease, there has been a paucity of pharmacometric …
recommended in patients with liver disease, there has been a paucity of pharmacometric …