Mitochondrial carriers (MCs) are a superfamily of nuclear-encoded proteins that are mostly
localized in the inner mitochondrial membrane and transport numerous metabolites …

Clinical manifestations typical of mitochondrial diseases are often present in various genetic
syndromes associated with intellectual disability, a condition leading to deficit in cognitive …

Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

Social impairment is frequently associated with mitochondrial dysfunction and altered
neurotransmission. Although mitochondrial function is crucial for brain homeostasis, it …

Background The diagnosis of autism spectrum disorder (ASD) at the earliest age possible is
important for initiating optimally effective intervention. In the United States the average age …

In the 1980s, after the mitochondrial DNA (mtDNA) had been sequenced, several diseases
resulting from mtDNA mutations emerged. Later, numerous disorders caused by mutations …

Autism spectrum disorder (ASD), the fastest growing developmental disability in the United
States, represents a group of neurodevelopmental disorders characterized by impaired …

In this review we discuss the structure and functions of the aspartate/glutamate carriers
(AGC1-aralar and AGC2-citrin). Those proteins supply the aspartate synthesized within …

Autism spectrum disorder (ASD) is a syndrome that affects normal brain development and is
characterized by impaired social interaction as well as verbal and non-verbal …

Mitochondria are the powerhouse that generate over 90% of the ATP produced in cells. In
addition to its role in energy production, the mitochondrion also plays a major role in …