Disinfection Byproducts of Haloacetaldehydes Disrupt Hepatic Lipid Metabolism and Induce Lipotoxicity in High-Fat Culture Conditions

L Yang, Z Jiang, L Yang, W Zheng… - Environmental …, 2024 - ACS Publications
Unhealthy lifestyles, obesity, and environmental pollutants are strongly correlated with the
development of nonalcoholic fatty liver disease (NAFLD). Haloacetaldehyde-associated …

Case report: Genetic analysis of PEG-asparaginase induced severe hypertriglyceridemia in an adult with acute lymphoblastic leukaemia

A Iannuzzi, M Annunziata, G Fortunato… - Frontiers in …, 2022 - frontiersin.org
PEG-Asparaginase (also known as Pegaspargase), along with glucocorticoids
(predominantly prednisolone or dexamethasone) and other chemotherapeutic agents (such …

[HTML][HTML] Induction of Cyp2e1 contributes to asparaginase-induced hepatocyte sensitization to lipotoxicity

Y Zhu, Y Wang, K Hoshitsuki, D Yang, L Kokai… - … Pharmaceutica Sinica B, 2024 - Elsevier
One of the leading therapies for acute lymphoblastic leukemia (ALL) is the
chemotherapeutic agent PEGylated E. coli-derived-L-asparaginase (PEG-ASNase). Due to …

Chemotherapy-Induced Liver Injury: Unveiling Emerging Mechanisms and Exploring Mitigation Strategies

MA Alkabbani, AAS Shatat, AN Ghazy… - ERU Research …, 2024 - erurj.journals.ekb.eg
In this comprehensive overview of chemotherapy-induced liver injury, various classes of
chemotherapeutic agents were reviewed to elucidate the complex cellular events …

Prise en charge des toxicités de la pégaspargase (hors anomalies de la coagulation). Recommandations du comité leucémie de la Société française de lutte contre …

M Poirée, F Neumann, C Thomas, P Simon… - Bulletin du …, 2022 - Elsevier
Résumé La pégaspargase (Oncaspar®), forme pégylée de la L-asparaginase issue
d'Escherichia Coli est un composant essentiel des polychimiothérapies utilisées dans le …

[引用][C] Investigating diet as a confounder to asparaginase treatment of acute lymphoblast leukemia

Z Forbrigger - 2023