Insights and opportunities for deep brain stimulation as a brain circuit intervention

WJ Neumann, A Horn, AA Kühn - Trends in Neurosciences, 2023 - cell.com
Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …

NIRS in clinical neurology—a 'promising'tool?

H Obrig - Neuroimage, 2014 - Elsevier
Near-infrared spectroscopy (NIRS) has become a relevant research tool in neuroscience. In
special populations such as infants and for special tasks such as walking, NIRS has …

Predicting optimal deep brain stimulation parameters for Parkinson's disease using functional MRI and machine learning

A Boutet, R Madhavan, GJB Elias, SE Joel… - Nature …, 2021 - nature.com
Commonly used for Parkinson's disease (PD), deep brain stimulation (DBS) produces
marked clinical benefits when optimized. However, assessing the large number of possible …

Full activation pattern mapping by simultaneous deep brain stimulation and fMRI with graphene fiber electrodes

S Zhao, G Li, C Tong, W Chen, P Wang, J Dai… - Nature …, 2020 - nature.com
Simultaneous deep brain stimulation (DBS) and functional magnetic resonance imaging
(fMRI) constitutes a powerful tool for elucidating brain functional connectivity, and exploring …

Deep brain stimulation induced normalization of the human functional connectome in Parkinson's disease

A Horn, G Wenzel, F Irmen, J Huebl, N Li, WJ Neumann… - Brain, 2019 - academic.oup.com
Neuroimaging has seen a paradigm shift away from a formal description of local activity
patterns towards studying distributed brain networks. The recently defined framework of the …

Resting state functional MRI in Parkinson's disease: the impact of deep brain stimulation on 'effective'connectivity

J Kahan, M Urner, R Moran, G Flandin, A Marreiros… - Brain, 2014 - academic.oup.com
Depleted of dopamine, the dynamics of the parkinsonian brain impact on both 'action'and
'resting'motor behaviour. Deep brain stimulation has become an established means of …

[HTML][HTML] Probing responses to deep brain stimulation with functional magnetic resonance imaging

A Loh, D Gwun, CT Chow, A Boutet, J Tasserie… - Brain stimulation, 2022 - Elsevier
Background Deep brain stimulation (DBS) is an established treatment for certain movement
disorders and has additionally shown promise for various psychiatric, cognitive, and seizure …

[HTML][HTML] Virtual deep brain stimulation: Multiscale co-simulation of a spiking basal ganglia model and a whole-brain mean-field model with The Virtual Brain

JM Meier, D Perdikis, A Blickensdörfer… - Experimental …, 2022 - Elsevier
Deep brain stimulation (DBS) has been successfully applied in various neurodegenerative
diseases as an effective symptomatic treatment. However, its mechanisms of action within …

[HTML][HTML] Clinical applications of magnetic resonance imaging based functional and structural connectivity

C Wu, F Ferreira, M Fox, N Harel, J Hattangadi-Gluth… - Neuroimage, 2021 - Elsevier
Advances in computational neuroimaging techniques have expanded the armamentarium of
imaging tools available for clinical applications in clinical neuroscience. Non-invasive, in …

Future of brain stimulation: new targets, new indications, new technology

M Hariz, P Blomstedt, L Zrinzo - Movement Disorders, 2013 - Wiley Online Library
In the last quarter of a century, DBS has become an established neurosurgical treatment for
Parkinson's disease (PD), dystonia, and tremors. Improved understanding of brain circuitries …