Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …

Simple Summary Antibody–drug conjugates (ADCs) are a growing class of therapies that
aim to delivery therapy more efficiently, with fewer side effects, than conventional …

Simple Summary Human epidermal growth factor receptor 2 (HER2)-positive metastatic
breast cancer (mBC) represents a subgroup of breast cancer characterized by an …

Human epidermal growth factor receptor 2 (HER2) is overexpressed in various cancer types.
HER2-targeting trastuzumab plus chemotherapy is used as first-line therapy for HER2 …

The human epidermal growth factor receptor 2 (HER2)–targeting trastuzumab emtansine (T-
DM1) and trastuzumab deruxtecan (T-DXd) are antibody–drug conjugates (ADC) clinically …

Previous studies have suggested tumoral caveolin-1 (CAV1) as a predictive biomarker for
the response to anti-HER2 antibody drug therapies in gastric tumors. In this study …

Abstract Caveolin-1 (Cav-1) is a critical lipid raft protein playing dual roles as both a tumor
suppressor and promoter. While its role in tumorigenesis, progression, and metastasis has …

Cholesterol is crucial for cell survival and growth, and dysregulation of cholesterol
homeostasis has been linked to the development of cancer. The tumor microenvironment …

Abstract microRNAs are candidate diagnostic biomarkers for Alzheimer's disease. This study
aimed to compare Silymarin with Rosuvastatin and placebo on total-Tau protein level and …

This MIB guide briefly summarizes the generation of patient-derived xenografts (PDXs) and
highlights the importance of validating PDX models for the presence of B cell lymphoma of …