Innervation: the missing link for biofabricated tissues and organs

S Das, WJ Gordián-Vélez, HC Ledebur… - NPJ Regenerative …, 2020 - nature.com
Innervation plays a pivotal role as a driver of tissue and organ development as well as a
means for their functional control and modulation. Therefore, innervation should be carefully …

Tissue engineering and biomaterial strategies to elicit endogenous neuronal replacement in the brain

EM Purvis, JC O'Donnell, HI Chen, DK Cullen - Frontiers in Neurology, 2020 - frontiersin.org
Neurogenesis in the postnatal mammalian brain is known to occur in the dentate gyrus of
the hippocampus and the subventricular zone. These neurogenic niches serve as …

Dysregulation of BRD4 function underlies the functional abnormalities of MeCP2 mutant neurons

Y Xiang, Y Tanaka, B Patterson, SM Hwang, E Hysolli… - Molecular cell, 2020 - cell.com
Rett syndrome (RTT), mainly caused by mutations in methyl-CpG binding protein 2
(MeCP2), is one of the most prevalent intellectual disorders without effective therapies. Here …

Toward a neurospheroid niche model: Optimizing embedded 3D bioprinting for fabrication of neurospheroid brain-like co-culture constructs

YCE Li, YA Jodat, R Samanipour, G Zorzi, K Zhu… - …, 2020 - iopscience.iop.org
A crucial step in creating reliable in vitro platforms for neural development and disorder
studies is the reproduction of the multicellular three-dimensional (3D) brain …

Tissue engineered bands of büngner for accelerated motor and sensory axonal outgrowth

KV Panzer, JC Burrell, KVT Helm, EM Purvis… - … in Bioengineering and …, 2020 - frontiersin.org
Following peripheral nerve injury comprising a segmental defect, the extent of axon
regeneration decreases precipitously with increasing gap length. Schwann cells play a key …

Involvement of anoikis in dissociated optic nerve fiber layer appearance

T Ikeda, K Nakamura, T Sato, T Kida, H Oku - International Journal of …, 2021 - mdpi.com
Dissociated optic nerve fiber layer (DONFL) appearance is characterized by dimpling of the
fundus when observed after vitrectomy with the internal limiting membrane (ILM) peeling in …

Generation of contractile forces by three-dimensional bundled axonal tracts in micro-tissue engineered neural networks

D Chouhan, WJ Gordián Vélez, LA Struzyna… - Frontiers in Molecular …, 2024 - frontiersin.org
Axonal extension and retraction are ongoing processes that occur throughout all
developmental stages of an organism. The ability of axons to produce mechanical forces …

An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement

JC O'Donnell, EM Purvis, KVT Helm… - Communications …, 2021 - nature.com
The rostral migratory stream (RMS) facilitates neuroblast migration from the subventricular
zone to the olfactory bulb throughout adulthood. Brain lesions attract neuroblast migration …

A three-dimensional tissue-engineered rostral migratory stream as an in vitro platform for subventricular zone-derived cell migration

EM Purvis, AD Garcia-Epelboim, EN Krizman… - … in Bioengineering and …, 2024 - frontiersin.org
In the brains of most adult mammals, neural precursor cells (NPCs) from the subventricular
zone (SVZ) migrate through the rostral migratory stream (RMS) to replace olfactory bulb …

Glia in Tissue Engineering: From Biomaterial Tools to Transplantation

AS Dill-Macky, EN Lee, JA Wertheim, KM Koss - Acta Biomaterialia, 2024 - Elsevier
Glia are imperative in nearly every function of the nervous system, including
neurotransmission, neuronal repair, development, immunity, and myelination. Recently, the …