Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1-3 G …

We show that amino acid covariation in proteins, extracted from the evolutionary sequence
record, can be used to fold transmembrane proteins. We use this technique to predict …

Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …

The structural basis of allosteric signaling in G protein-coupled receptors (GPCRs) is
important in guiding design of therapeutics and understanding phenotypic consequences of …

Application of genetic distances to measure phenotypic relatedness is a challenging task,
reflecting the complex relationship between genotype and phenotype. Accurate assessment …

Structural genomics projects have solved many new structures with unknown functions. One
strategy to investigate the function of a structure is to computationally find the functionally …

Protein structure networks (PSNs) were widely used in analyses of protein structure and
function. In this work, we analyzed and compared the characters of PSNs by different …

An All-Inclusive Review of the Achievements and Trends in the Fast-Growing Protein
Engineering Field From humble beginnings like making fire for mere survival, engineering …

The activities and properties of proteins are the result of interactions among their constitutive
amino acids. In the course of natural selection, substitutions which tend to destabilize a …

We present an algorithm EcSymDock which optimized SymDock using Evolution couplings
for better performance. SymDock is a protocol of Rosetta used to predict protein oligomer …