Malaria is a complex parasitic disease, caused by Plasmodium spp. More than a century
after the discovery of malaria parasites, this disease continues to pose a global public health …

Malaria parasites exhibit a complex lifecycle, requiring extensive asexual replication in the
liver and blood of the vertebrate host, and in the haemocoel of the insect vector. Yet, they …

Infection with Plasmodium falciparum enhances extracellular vesicle (EV) production in
parasitized red blood cells (pRBCs), an important mechanism for parasite-to-parasite …

In infectious diseases, extracellular vesicles (EVs) released from a pathogen or pathogen-
infected cells can transfer pathogen-derived biomolecules, especially proteins, to target cells …

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. The disease has
an acute and a chronic phase in which approximately 30% of the chronic patients suffer from …

Abstract Background Extracellular vesicles (EVs) have been broadly studied in malaria for
nearly a decade. These vesicles carry various functional biomolecules including RNA …

One of the major pathophysiologies of malaria is the development of anemia. Although
hemolysis and splenic clearance are well described as causes of malarial anemia …

Laboratory studies of pathogens aim to limit complexity in order to disentangle the important
parameters contributing to an infection. However, pathogens rarely exist in isolation, and …

Extracellular vesicles (EVs) are minute particles secreted by the cells of living organisms.
Although the functional role of EVs is not yet clear, recent work has highlighted their role in …

Severe malarial anemia (SMA) is the main cause of malaria-associated infant mortality in
malaria endemic countries. One major factor that contributes to SMA is the accumulation of …