Mitophagy is an essential mitochondrial quality control mechanism that eliminates damaged
mitochondria and the production of reactive oxygen species (ROS). The relationship …

Recent advances in understanding the role of mitochondrial dysfunction in
neurodegenerative diseases have expanded the opportunities for neurotherapeutics …

Alzheimer's disease (AD) is an insidious and progressive neurodegenerative disorder that
affects millions of people worldwide. Although the pathogenesis remains obscure, there are …

Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

Background Brain energy metabolism is impaired in Alzheimer's disease (AD), which may
be mitigated by a ketogenic diet. We conducted a randomized crossover trial to determine …

Mitochondrial dysfunction is becoming one of the most emerging pathological process in the
etiology of neurological disorders. Other common etiologies of the neurological disorders …

A large body of literature supports the idea that nuclear factor kappa B (NF-κB) signaling
contributes to not only immunity, but also inflammation, cancer, and nervous system function …

Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …