Advances in genome editing through control of DNA repair pathways
Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage.
Advancements in genome editing take advantage of these pathways to produce permanent …
Advancements in genome editing take advantage of these pathways to produce permanent …
Mechanism and regulation of DNA end resection in eukaryotes
LS Symington - Critical reviews in biochemistry and molecular …, 2016 - Taylor & Francis
The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …
53BP1: a DSB escort
Z Mirman, T de Lange - Genes & development, 2020 - genesdev.cshlp.org
Abstract 53BP1 is an enigmatic DNA damage response factor that gained prominence
because it determines the efficacy of PARP1 inhibitory drugs (PARPi) in BRCA1-deficient …
because it determines the efficacy of PARP1 inhibitory drugs (PARPi) in BRCA1-deficient …
Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair
DNA double-strand break (DSB) repair is essential for maintaining our genomes. Mre11-
Rad50-Nbs1 (MRN) and Ku70-Ku80 (Ku) direct distinct DSB repair pathways, but the …
Rad50-Nbs1 (MRN) and Ku70-Ku80 (Ku) direct distinct DSB repair pathways, but the …
53BP1, BRCA1, and the choice between recombination and end joining at DNA double-strand breaks
JM Daley, P Sung - Molecular and cellular biology, 2014 - Taylor & Francis
When DNA double-strand breaks occur, the cell cycle stage has a major influence on the
choice of the repair pathway employed. Specifically, nonhomologous end joining is the …
choice of the repair pathway employed. Specifically, nonhomologous end joining is the …
DNA end resection: nucleases team up with the right partners to initiate homologous recombination
P Cejka - Journal of Biological Chemistry, 2015 - ASBMB
The repair of DNA double-strand breaks by homologous recombination commences by
nucleolytic degradation of the 5′-terminated strand of the DNA break. This leads to the …
nucleolytic degradation of the 5′-terminated strand of the DNA break. This leads to the …
Quantitation of DNA double-strand break resection intermediates in human cells
Abstract 5′ strand resection at DNA double strand breaks (DSBs) is critical for homologous
recombination (HR) and genomic stability. Here we develop a novel method to quantitatively …
recombination (HR) and genomic stability. Here we develop a novel method to quantitatively …
Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond
R Dueva, G Iliakis - NAR cancer, 2020 - academic.oup.com
Single-stranded DNA (ssDNA) forms continuously during DNA replication and is an
important intermediate during recombination-mediated repair of damaged DNA. Replication …
important intermediate during recombination-mediated repair of damaged DNA. Replication …
Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
P Chanut, S Britton, J Coates, SP Jackson… - Nature …, 2016 - nature.com
Repair of single-ended DNA double-strand breaks (seDSBs) by homologous recombination
(HR) requires the generation of a 3′ single-strand DNA overhang by exonuclease activities …
(HR) requires the generation of a 3′ single-strand DNA overhang by exonuclease activities …
Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection
N Makharashvili, AT Tubbs, SH Yang, H Wang… - Molecular cell, 2014 - cell.com
The carboxy-terminal binding protein (CtBP)-interacting protein (CtIP) is known to function in
5′ strand resection during homologous recombination, similar to the budding yeast Sae2 …
5′ strand resection during homologous recombination, similar to the budding yeast Sae2 …