Cancer is a group of diseases in which cells divide continuously and excessively. Cell
division is tightly regulated by multiple evolutionarily conserved cell cycle control …

The observation and analysis of intra-tumour heterogeneity (ITH), particularly in genomic
studies, has advanced our understanding of the evolutionary forces that shape cancer …

Cancer is driven by multiple types of genetic alterations, which range in size from point
mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome …

To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones
mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the …

Chromosomal instability (CIN) is a hallmark of human cancer, and it is associated with poor
prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome …

Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer
medicine. Here, we review data and technologies that have revealed intra-tumor …

Patient-derived xenografts (PDXs) have become a prominent cancer model system, as they
are presumed to faithfully represent the genomic features of primary tumors. Here we …

Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …

Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in
cancer cells. Alterations in chromosome copy number induce a wide variety of cellular …

Intratumor heterogeneity (ITH) drives neoplastic progression and therapeutic resistance. We
used the bioinformatics tools' expanding ploidy and allele frequency on nested …