Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

Pruritus (or itch) is an unpleasant sensation leading to a desire to scratch. In the epidermis,
there are selective C or Aδ epidermal nerve endings that are pruriceptors. At their other …

Animal studies have suggested that transient receptor potential ion channels and G-protein
coupled receptors play important roles in itch transmission. TRPV3 gain-of-function …

Background Thymic stromal lymphopoietin (TSLP) promotes TH 2 inflammation and is
deeply intertwined with inflammatory dermatoses like atopic dermatitis. The mechanisms …

PAR2 has been proposed to contribute to lesion formation and intense itch in atopic
dermatitis. Here, we tested the ability of a cell-penetrating pepducin, PZ-235, to mitigate the …

Eosinophilic esophagitis (EoE) is a chronic, food antigen–driven, inflammatory disease of
the esophagus and is associated with impaired barrier function. Evidence is emerging that …

Dysfunctional skin barrier and impaired skin homeostasis may lead to or aggravate a series
of dermatologic diseases. A large variety of biological events and bioactive molecules are …

Pruritus is a common and painful symptom in psoriasis with profoundly negative impacts on
quality of life. The underlying mechanisms of pruritus are complex and multifactorial, and …

Atopic dermatitis (AD) is an inflammatory, pruritic, chronic or chronically relapsing skin
disease that typically begins in early childhood and is occurring frequently in families with …

Abstract Poly (ADP‐ribose) polymerase‐1 (PARP1) is a pro‐inflammatory protein, whose
pro‐inflammatory properties were demonstrated in human. The pro‐inflammatory properties …