Epithelial–mesenchymal transition (EMT) is recognized as a driving force of cancer cell
metastasis and drug resistance, two leading causes of cancer recurrence and cancer …

Melanoma is a highly aggressive cancer with the poorest prognosis, representing the
deadliest form of skin cancer. Activating mutations in BRAF are the most frequent genetic …

Abstract Background Cancer-associated fibroblasts (CAFs) are tumor-promoting and
correlate with poor survival in many cancers, which has led to their emergence as potential …

The high number of somatic mutations in the melanoma genome associated with cumulative
ultra violet (UV) exposure has rendered it one of the most difficult of cancers to treat. With …

Cutaneous melanoma (CM) is a highly aggressive and drug resistant solid tumor, showing
an impressive metabolic plasticity modulated by oncogenic activation. In particular …

Macrophages (MO) are versatile cells, assuming distinct functional phenotypes depending
on the activating stimulus and the microenvironment. The differential activation of …

Abstract Background Hepatitis B virus (HBV) has a crucial role in the progression of
hepatocellular carcinoma (HCC). Tumour cells must develop anoikis resistance in order to …

The actin cytoskeleton of eukaryotic cells is a dynamic, fibrous network that is regulated by
the concerted action of actin-binding proteins (ABPs). In particular, rapid polarization of cells …

The acquisition of resistance to anoikis, the cell death induced by loss of adhesion to the
extracellular matrix, is an absolute requirement for the survival of disseminating and …

In this study, we aimed to develop an invasion-related risk signature and prognostic model
for personalized treatment and prognosis prediction in skin cutaneous melanoma (SKCM) …