Bacterial terpenome

JD Rudolf, TA Alsup, B Xu, Z Li - Natural product reports, 2021 - pubs.rsc.org
Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

Chemical Synthesis of Cell Wall Constituents of Mycobacterium tuberculosis

M Holzheimer, J Buter, AJ Minnaard - Chemical reviews, 2021 - ACS Publications
The pathogen Mycobacterium tuberculosis (Mtb), causing tuberculosis disease, features an
extraordinary thick cell envelope, rich in Mtb-specific lipids, glycolipids, and glycans. These …

[HTML][HTML] A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages

M Bedard, S van der Niet, EM Bernard… - The Journal of …, 2023 - Am Soc Clin Investig
Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB)
disease, which involves the transformation of infected phagolysosomes from a site of killing …

Antiinfectives targeting enzymes and the proton motive force

X Feng, W Zhu, LA Schurig-Briccio… - Proceedings of the …, 2015 - National Acad Sciences
There is a growing need for new antibiotics. Compounds that target the proton motive force
(PMF), uncouplers, represent one possible class of compounds that might be developed …

Diagnosis of tuberculosis in HIV co‐infected individuals: current status, challenges and opportunities for the future

P Méndez‐Samperio - Scandinavian journal of immunology, 2017 - Wiley Online Library
Tuberculosis (TB) remains one of the most important causes of death among people co‐
infected with human immunodeficiency virus (HIV). The diagnosis of TB remains challenging …

[HTML][HTML] Mycobacterium tuberculosis releases an antacid that remodels phagosomes

J Buter, TY Cheng, M Ghanem, AE Grootemaat… - Nature chemical …, 2019 - nature.com
Mycobacterium tuberculosis (Mtb) is the world's most deadly pathogen. Unlike less virulent
mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an unusual terpene …

[HTML][HTML] Halimane diterpenoids: sources, structures, nomenclature and biological activities

AM Roncero, IE Tobal, RF Moro, D Díez… - Natural product …, 2018 - pubs.rsc.org
Covering: 1970 to 2017 Diterpenes with a halimane skeleton constitute a small group of
natural products that can be biogenetically considered as being between labdane and …

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids

KS Wun, JF Reijneveld, TY Cheng, K Ladell… - Nature …, 2018 - nature.com
The hallmark function of αβ T cell antigen receptors (TCRs) involves the highly specific co-
recognition of a major histocompatibility complex molecule and its carried peptide. However …

[HTML][HTML] Sulphides from garlic essential oil dose-dependently change the distribution of glycerophospholipids and induce N6-tuberculosinyladenosine formation in …

R Sawicki, J Widelski, W Truszkiewicz, S Kawka… - Scientific Reports, 2023 - nature.com
The antimicrobial properties of garlic are widely known, and numerous studies confirmed its
ability to inhibit the growth of Mycobacterium tuberculosis. In this work, we explored the …

Cytokinin nucleosides-natural compounds with a unique spectrum of biological activities

MS Drenichev, VE Oslovsky… - Current topics in …, 2016 - ingentaconnect.com
Cytokinin nucleosides exhibit antitumor, antiviral, antiprotozoal, blood pressure reducing,
anti-inflammatory, and antipsychotic activity. These compounds also influence platelet …