Enabling technology and core theory of synthetic biology
Synthetic biology provides a new paradigm for life science research (“build to learn”) and
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …
Community guidelines for GPCR ligand bias: IUPHAR review 32
P Kolb, T Kenakin, SPH Alexander… - British journal of …, 2022 - Wiley Online Library
GPCRs modulate a plethora of physiological processes and mediate the effects of one‐third
of FDA‐approved drugs. Depending on which ligand activates a receptor, it can engage …
of FDA‐approved drugs. Depending on which ligand activates a receptor, it can engage …
Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor
Y Lee, T Warne, R Nehmé, S Pandey… - Nature, 2020 - nature.com
Abstract The β1-adrenoceptor (β1AR) is a G-protein-coupled receptor (GPCR) that couples
to the heterotrimeric G protein Gs. G-protein-mediated signalling is terminated by …
to the heterotrimeric G protein Gs. G-protein-mediated signalling is terminated by …
Structural snapshots uncover a key phosphorylation motif in GPCRs driving β-arrestin activation
Agonist-induced GPCR phosphorylation is a key determinant for the binding and activation
of β-arrestins (βarrs). However, it is not entirely clear how different GPCRs harboring …
of β-arrestins (βarrs). However, it is not entirely clear how different GPCRs harboring …
β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells
Abstract β-arrestins mediate regulatory processes for over 800 different G protein-coupled
receptors (GPCRs) by adopting specific conformations that result from the geometry of the …
receptors (GPCRs) by adopting specific conformations that result from the geometry of the …
[HTML][HTML] Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors
G-protein-coupled receptors (GPCRs), also known as seven transmembrane receptors
(7TMRs), typically interact with two distinct signal-transducers, ie, G proteins and β-arrestins …
(7TMRs), typically interact with two distinct signal-transducers, ie, G proteins and β-arrestins …
Plasma membrane preassociation drives β-arrestin coupling to receptors and activation
Summary β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and
desensitization. Despite recent structural advances, the mechanisms that govern receptor-β …
desensitization. Despite recent structural advances, the mechanisms that govern receptor-β …
G protein-coupled receptor signaling: transducers and effectors
G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in
a wide range of physiological functions and in a large number of Food and Drug …
a wide range of physiological functions and in a large number of Food and Drug …
Emerging structural insights into GPCR–β-arrestin interaction and functional outcomes
Agonist-induced recruitment of β-arrestins (βarrs) to G protein-coupled receptors (GPCRs)
plays a central role in regulating the spatio-temporal aspects of GPCR signaling. Several …
plays a central role in regulating the spatio-temporal aspects of GPCR signaling. Several …
Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling
Agonist-induced phosphorylation of G protein–coupled receptors (GPCRs) is a key
determinant for their interaction with β-arrestins (βarrs) and subsequent functional …
determinant for their interaction with β-arrestins (βarrs) and subsequent functional …