Hormone receptor (HR)‐positive and human epidermal growth factor receptor 2 (HER2)‐
negative breast cancer is defined by the presence of the estrogen receptor and/or the …

In breast cancer, mAbs can play multifunctional roles like targeting cancer cells, sometimes
directly attacking them, helping in locating and delivering therapeutic drugs to targets …

Background A phase 2 study showed that progression-free survival was longer with
palbociclib plus letrozole than with letrozole alone in the initial treatment of postmenopausal …

Background We previously reported prolonged progression-free survival and marginally
prolonged overall survival among postmenopausal patients with hormone receptor–positive …

Angiogenesis is one of the hallmarks of cancer and a crucial requisite in the development of
tumors. Interrupting this process by blocking the vascular endothelial growth factor (VEGF) …

Dysregulation of the cell cycle is a hallmark of cancer that leads to aberrant cellular
proliferation. CDK4/6 are cyclin-dependent kinases activated in response to proliferative …

Tumors induce angiogenesis to acquire oxygen and nutrition from their adjacent
microenvironment. Tumor angiogenesis has been believed to be induced primarily by the …

Purpose Despite increasing awareness of accrual challenges, it is unknown if accrual of
older patients to breast cancer treatment trials is improving. Methods We examined accrual …

Metastatic breast cancer is one of the most common and well-known causes of death for
women worldwide. The inflammatory tumor cell and other cancer hallmarks dictate the …

Simple Summary We provide an extensive review of the fundamental principles of statistical
science that are needed to accurately interpret randomized controlled trials (RCTs). We use …