Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer
patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the …

Psoriasis can be a socially isolating disease due to debilitating physical symptoms and the
stigma patients feel because of the appearance of their skin. Mental health comorbidities …

The concept that intestinal microbial composition not only affects the health of the gut, but
also influences centrally-mediated systems involved in mood, is supported by a growing …

BACKGROUND: Depressive disorders are associated with immune system alterations that
can be detected in the blood. Cytokine concentrations in cerebrospinal fluid (CSF) and their …

Postnatal neurogenesis can be modulated after brain injury, but the role of the attendant
expression of inflammatory mediators in such responses remains to be determined. Here we …

Almost a quarter of a century ago, interleukin-6 (IL-6) was discovered as an inflammatory
cytokine involved in B cell differentiation. Today, IL-6 is recognized to be a highly versatile …

Cytokine-dependent mechanisms in the CNS have been implicated in the pathogenesis of
depression. Interleukin-6 is upregulated in depressed patients and dowregulated by …

The occurrence, progression and recurrence of psoriasis are thought to be related to mood
and psychological disorders such as depression. Psoriasis can lead to depression, and …

Increasing evidence suggests that the detrimental effects of glucocorticoid (GC)
hypersecretion occur by activation of the hypothalamic-pituitary-adrenal (HPA) axis in …

Aims/hypothesis Interleukin-6 is an inflammatory cytokine with pleiotropic effects upon
nutrient homeostasis. Many reports show that circulating IL6 correlates with obesity and …