Integrated analysis of transcriptomic and proteomic data
Until recently, understanding the regulatory behavior of cells has been pursued through
independent analysis of the transcriptome or the proteome. Based on the central dogma, it …
independent analysis of the transcriptome or the proteome. Based on the central dogma, it …
Gene regulatory network inference: data integration in dynamic models—a review
M Hecker, S Lambeck, S Toepfer, E Van Someren… - Biosystems, 2009 - Elsevier
Systems biology aims to develop mathematical models of biological systems by integrating
experimental and theoretical techniques. During the last decade, many systems biological …
experimental and theoretical techniques. During the last decade, many systems biological …
Lymphotoxin β receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE−/− mice
R Gräbner, K Lötzer, S Döpping, M Hildner… - Journal of Experimental …, 2009 - rupress.org
Atherosclerosis involves a macrophage-rich inflammation in the aortic intima. It is
increasingly recognized that this intimal inflammation is paralleled over time by a distinct …
increasingly recognized that this intimal inflammation is paralleled over time by a distinct …
Integrating transcriptome and proteome profiling: Strategies and applications
Discovering the gene expression signature associated with a cellular state is one of the
basic quests in majority of biological studies. For most of the clinical and cellular …
basic quests in majority of biological studies. For most of the clinical and cellular …
Systems pharmacology in drug discovery and therapeutic insight for herbal medicines
Abstract Systems pharmacology is an emerging field that integrates systems biology and
pharmacology to advance the process of drug discovery, development and the …
pharmacology to advance the process of drug discovery, development and the …
Passing messages between biological networks to refine predicted interactions
Regulatory network reconstruction is a fundamental problem in computational biology.
There are significant limitations to such reconstruction using individual datasets, and …
There are significant limitations to such reconstruction using individual datasets, and …
Branched-chain amino acid catabolism is a conserved regulator of physiological ageing
J Mansfeld, N Urban, S Priebe, M Groth… - Nature …, 2015 - nature.com
Ageing has been defined as a global decline in physiological function depending on both
environmental and genetic factors. Here we identify gene transcripts that are similarly …
environmental and genetic factors. Here we identify gene transcripts that are similarly …
Longitudinal RNA-Seq analysis of vertebrate aging identifies mitochondrial complex I as a small-molecule-sensitive modifier of lifespan
M Baumgart, S Priebe, M Groth, N Hartmann, U Menzel… - Cell Systems, 2016 - cell.com
Mutations and genetic variability affect gene expression and lifespan, but the impact of
variations in gene expression within individuals on their aging-related mortality is poorly …
variations in gene expression within individuals on their aging-related mortality is poorly …
RNA‐seq of the aging brain in the short‐lived fish N. furzeri – conserved pathways and novel genes associated with neurogenesis
The brains of teleost fish show extensive adult neurogenesis and neuronal regeneration.
The patterns of gene regulation during fish brain aging are unknown. The short‐lived teleost …
The patterns of gene regulation during fish brain aging are unknown. The short‐lived teleost …
[图书][B] Feedback control in systems biology
C Cosentino, D Bates - 2011 - books.google.com
Like engineering systems, biological systems must also operate effectively in the presence
of internal and external uncertainty—such as genetic mutations or temperature changes, for …
of internal and external uncertainty—such as genetic mutations or temperature changes, for …