Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …

The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …

Despite tremendous research advancements in nonalcoholic fatty liver disease (NAFLD),
our understanding of sex differences in NAFLD remains insufficient. This review summarizes …

Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote the
progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte …

Background & Aims Angiocrine signaling by liver sinusoidal endothelial cells (LSECs)
regulates hepatic functions such as growth, metabolic maturation, and regeneration …

Liver fibrosis is a common feature of sustained liver injury and represents a major public
health problem worldwide. Fibrosis is an active research field and discoveries in the last …

Hepatic fibrosis is characterized by the pathological accumulation of extracellular matrix
(ECM) in the liver resulting from the persistent liver injury and wound-healing reaction …

Abstract Background Long noncoding RNAs (lncRNAs) have emerged as important
regulators in a variety of human diseases. The dysregulation of liver sinusoidal endothelial …

Abstract 'Angiodiversity'refers to the structural and functional heterogeneity of endothelial
cells (EC) along the segments of the vascular tree and especially within the microvascular …

Bone morphogenetic protein 9 (BMP9) is a circulating factor produced by hepatic stellate
cells that plays a critical role in vascular quiescence through its endothelial receptor activin …