Schizosaccharomyces pombe (fission yeast) is an attractive model for mitochondrial
research. The organism resembles human cells in terms of mitochondrial inheritance …

The functional and structural relationship among the individual components of the
mitochondrial respiratory chain constitutes a central aspect of our understanding of aerobic …

Recent studies have established that cellular electrostatic interactions are more influential
than assumed previously. Here, we use cryo-EM and perform steady-state kinetic studies to …

Cytochrome c oxidase (CytcO) is an integral membrane protein, which catalyzes four-
electron reduction of oxygen linked to proton uptake and pumping. Amphipathic molecules …

The terminal oxidases of bacterial aerobic respiratory chains are redox-active electrogenic
enzymes that catalyze the four-electron reduction of O2 to 2H2O taking out electrons from …

Ten years ago, the term “resolution revolution” was used for the first time to describe how
cryogenic electron microscopy (cryo-EM) marked the beginning of a new era in the field of …

Respiratory complexes have co-evolved into supercomplexes in different clades to sustain
energy production at the basis of eukaryotic life. In parasites, they likely exhibit functional …

The mitochondrial respiratory chain (MRC) enzymatic complexes, essential for aerobic
energy transduction in eukaryotic cells, are organized into evolutionarily conserved higher …

The leading cause of bacterial meningitis, Neisseria meningitidis, deploys a quinol
dependent nitric oxide reductase (Nm qNOR), belonging to the heme-copper oxidase …

In eukaryotes, oxygen consumption is mainly driven by the respiratory activity of
mitochondria, which generates most of the cellular energy that sustains life. This parameter …