The power of using functional fMRI on small rodents to study brain pharmacology and disease
Functional magnetic resonance imaging (fMRI) is an excellent tool to study the effect of
pharmacological modulations on brain function in a non-invasive and longitudinal manner …
pharmacological modulations on brain function in a non-invasive and longitudinal manner …
Cell type-specific transcriptomics reveals that mutant huntingtin leads to mitochondrial RNA release and neuronal innate immune activation
The mechanisms by which mutant huntingtin (mHTT) leads to neuronal cell death in
Huntington's disease (HD) are not fully understood. To gain new molecular insights, we …
Huntington's disease (HD) are not fully understood. To gain new molecular insights, we …
[HTML][HTML] Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver
The hippocampus in schizophrenia is characterized by both hypermetabolism and reduced
size. It remains unknown whether these abnormalities are mechanistically linked. Here we …
size. It remains unknown whether these abnormalities are mechanistically linked. Here we …
A segmentation protocol and MRI atlas of the C57BL/6J mouse neocortex
The neocortex is the largest component of the mammalian cerebral cortex. It integrates
sensory inputs with experiences and memory to produce sophisticated responses to an …
sensory inputs with experiences and memory to produce sophisticated responses to an …
[HTML][HTML] Magnetic resonance imaging of Huntington's disease: preparing for clinical trials
S Kloeppel, SM Henley, NZ Hobbs, RC Wolf… - Neuroscience, 2009 - Elsevier
The known genetic mutation causing Huntington's disease (HD) makes this disease an
important model to study links between gene and brain function. An autosomal dominant …
important model to study links between gene and brain function. An autosomal dominant …
Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice
N Itoh, Y Itoh, CE Meyer, TT Suen… - Nature …, 2023 - nature.com
Menopause is associated with cognitive deficits and brain atrophy, but the brain region and
cell-specific mechanisms are not fully understood. Here, we identify a sex hormone by age …
cell-specific mechanisms are not fully understood. Here, we identify a sex hormone by age …
An in vivo MRI Template Set for Morphometry, Tissue Segmentation, and fMRI Localization in Rats
PA Valdés-Hernández, A Sumiyoshi… - Frontiers in …, 2011 - frontiersin.org
Over the last decade, several papers have focused on the construction of highly detailed
mouse high field magnetic resonance image (MRI) templates via non-linear registration to …
mouse high field magnetic resonance image (MRI) templates via non-linear registration to …
Voxel-based morphometry predicts shifts in dendritic spine density and morphology with auditory fear conditioning
Neuroimaging has provided compelling data about the brain. Yet the underlying
mechanisms of many neuroimaging techniques have not been elucidated. Here we report a …
mechanisms of many neuroimaging techniques have not been elucidated. Here we report a …
[HTML][HTML] Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota
J Liu, T Zhang, Y Wang, C Si, X Wang, RT Wang… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
We investigated the neuroprotective effects of baicalin and the role of gut microbiota in a
mouse model of cerebral ischemia-reperfusion injury. Repeated cerebral ischemia …
mouse model of cerebral ischemia-reperfusion injury. Repeated cerebral ischemia …
Robust automatic rodent brain extraction using 3-D pulse-coupled neural networks (PCNN)
Brain extraction is an important preprocessing step for further processing (eg, registration
and morphometric analysis) of brain MRI data. Due to the operator-dependent and time …
and morphometric analysis) of brain MRI data. Due to the operator-dependent and time …