A decennary update on diverse heterocycles and their intermediates as privileged scaffolds for cathepsin B inhibition
The identification of x-ray crystal structure of cathepsin B (CTSB) in the early 90's enabled
researchers to embark on a journey to understand and demystify its multiple catalytic …
researchers to embark on a journey to understand and demystify its multiple catalytic …
Some morpholine tethered novel aurones: Design, synthesis, biological, kinetic and molecular docking studies
Enzymes are the biological macromolecules that have emerged as an important drug target
as their upregulation/imbalance leads to various pathological conditions, such as …
as their upregulation/imbalance leads to various pathological conditions, such as …
Triazole: a new perspective in medicinal chemistry and material science
PA Bezerra Morais, CL Javarini, TC Valim… - Current Organic …, 2022 - benthamdirect.com
Triazole, which can exist in two isomeric forms: 1, 2, 3-and 1, 2, 4-triazole, is considered to
be a privileged scaffold with recognized biological and pharmaceutical potential …
be a privileged scaffold with recognized biological and pharmaceutical potential …
1, 2, 3-triazole clubbed and dichloro substituted novel aurones as potential anticancer agents targeting digestive enzymes: Design, synthesis, DFT, ADME and …
In the present investigation, we engineered some 1, 2, 3-triazole clubbed and dichloro
substituted novel aurones as potential anticancer agents well capable of targeting digestive …
substituted novel aurones as potential anticancer agents well capable of targeting digestive …
Keto-bridged dual triazole-linked benzenesulfonamides as potent carbonic anhydrase and cathepsin B inhibitors
L Vats, P Arya, R Kumar, S Giovannuzzi… - Future Medicinal …, 2023 - Taylor & Francis
Background: Inhibition of human carbonic anhydrase (hCA) isoforms IX and XII with
concurrent inhibition of cathepsin B is a promising approach for targeting cancers …
concurrent inhibition of cathepsin B is a promising approach for targeting cancers …
Synthetic and Biological Studies of Some Pyrrolidine-Tethered Novel Aurones against Digestive Enzymes
Amylase, lipase, and trypsin are crucial digestive enzymes, whose activation or inhibition is
of potent therapeutic approach for treating various body disorders. In this work, we have …
of potent therapeutic approach for treating various body disorders. In this work, we have …
Design, synthesis, molecular docking and biological studies of some novel pyrrolidine-triazole-aurone hybrids against digestive enzymes
Here in this work we successfully designed and synthesized a library of some novel
pyrrolidine-triazole-aurone hybrids ie (Z)-2-benzylidene-6-((1-(2-(pyrrolidin-1-yl) ethyl)-1 H …
pyrrolidine-triazole-aurone hybrids ie (Z)-2-benzylidene-6-((1-(2-(pyrrolidin-1-yl) ethyl)-1 H …
Benzenesulfonamides functionalized with triazolyl‐linked pyrazoles possess dual cathepsin B and carbonic anhydrase inhibitory action
The design and synthesis of a library of 21 novel benzenesulfonamide‐bearing 3‐
functionalized pyrazole‐linked 1, 2, 3‐triazole derivatives as dual inhibitors of cathepsin B …
functionalized pyrazole‐linked 1, 2, 3‐triazole derivatives as dual inhibitors of cathepsin B …
Development of benzenesulfonamide containing 1, 2, 3-triazole and 1, 3, 4-oxadiazole hybrids as cathepsin B inhibitors and DFT calculations
A series of twenty-one novel hybrids of 1, 2, 3-triazole, 1, 3, 4-oxadiazole, and
benzenesulfonamide motifs has been synthesized and evaluated for inhibitory potency …
benzenesulfonamide motifs has been synthesized and evaluated for inhibitory potency …
1, 2, 3‐Triazole‐Based New Aurones as Anticancer Agents with the Capability to Target Extracellular Digestive Enzymes
This study involves the synthesis of a series of dimethyl substituted novel aurones, featuring
1, 2, 3‐triazole as an integral structure. All the newly synthesized compounds were …
1, 2, 3‐triazole as an integral structure. All the newly synthesized compounds were …