Vaccines based on historical virus isolates provide limited protection from continuously
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …

As the fifth variant of concern of the SARS‐CoV‐2 virus, the Omicron variant (B. 1.1. 529)
has quickly become the dominant type among the previous circulating variants worldwide …

The continuing emergence of SARS-CoV-2 variants highlights the need to update COVID-19
vaccine compositions. However, immune imprinting induced by vaccination based on the …

Convergent evolution of SARS-CoV-2 Omicron BA. 2, BA. 4, and BA. 5 lineages has led to
the emergence of several new subvariants, including BA. 2.75. 2, BA. 4.6. and BQ. 1.1. The …

Omicron subvariants continuingly challenge current vaccination strategies. Here, we
demonstrate nearly complete escape of the XBB. 1.5, CH. 1.1, and CA. 3.1 variants from …

The protective efficacy of serum antibodies results from the interplay of antigen-specific B
cell clones of different affinities and specificities. These cellular dynamics underlie serum …

Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with
antigenic changes in the spike protein are neutralized less efficiently by serum antibodies …

Evolution of SARS-CoV-2 requires the reassessment of current vaccine measures. Here, we
characterized BA. 2.86 and XBB-derived variant FLip by investigating their neutralization …

Immune evasion by SARS-CoV-2 paired with immune imprinting from monovalent mRNA
vaccines has resulted in attenuated neutralizing antibody responses against Omicron …

ABSTRACT The highly mutated BA. 2.86, with over 30 spike protein mutations in
comparison to Omicron BA. 2 and XBB. 1.5 variants, has raised concerns about its potential …