Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …

Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels
forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to …

Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …

Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

Notch pathway is an evolutionarily conserved signalling system that operates to influence an
astonishing array of cell fate decisions in different developmental contexts. Notch signalling …

Objective—Endothelial cells (ECs), pericytes, and vascular smooth muscle cells (vSMCs)
are essential for vascular development, and their dysfunction causes multiple cardiovascular …

Cerebrovascular dysfunction is strongly associated with neonatal intracranial hemorrhage
(ICH) and stroke in adults. Cerebrovascular endothelial cells (ECs) play important roles in …

Calcific aortic valve disease (CAVD) is a major contributor to cardiovascular morbidity and
mortality and, given its association with age, the prevalence of CAVD is expected to continue …

Rationale: Neuregulin-1 (NRG-1) includes an extracellular epidermal growth factor–like
domain and an intracellular domain (NRG-1-ICD). In response to transforming growth factor …

Molecular pathways that control the specification, migration, and number of available
smooth muscle progenitor cells play key roles in determining blood vessel size and …