Staphylococcus aureus is an important pathogen that leads to significant disease through
multiple routes of infection. We recently published a transposon sequencing (Tn-seq) screen …

Iron (Fe) is a trace nutrient required by nearly all organisms. As a result of the demand for Fe
and the toxicity of non-chelated cytosolic ionic Fe, regulatory systems have evolved to tightly …

Chlorhexidine dodecyl sulfate (CHX-DS) was synthesized and characterized via single-
crystal X-ray diffraction (SC-XRD), 1H nuclear magnetic resonance (NMR) spectroscopy, 1H …

The need for novel antimalarials is apparent given the continuing disease burden
worldwide, despite significant drug discovery advances from the bench to the bedside. In …

To gain a better insight of how Copper (Cu) ions toxify cells, metabolomic analyses were
performed in S. aureus strains that lacks the described Cu ion detoxification systems (Δ …

Rickettsia is a genus of Gram-negative bacteria that has for centuries caused large-scale
morbidity and mortality. In recent years, the resurgence of rickettsial diseases as a major …

Background Stenotrophomonas maltophilia is ubiquitous in the environment and is an
important MDR opportunistic pathogen. Oxidative stress is an inevitable challenge to an …

The conditionally essential pathway of bacterial cysteine biosynthesis is gaining traction for
the development of antibiotic adjuvants. Bacterial cysteine biosynthesis is generally …

The extent to which a drug accumulates in Mycobacterium tuberculosis (Mtb) and its host
cell can affect treatment efficacy. We describe protocols measuring drug accumulation in …

Iron (Fe) is an essential nutrient for nearly all organisms. Cytosolic Fe overload can cause
toxicity through Fenton chemistry and/or the mismetalation of enzymes. 1 Because of this …