Electronic cigarette use has dramatically increased over the last decade. With this recent
technological development and wide range of constituents in various products, putative …

The cholinergic system plays a crucial role in nervous system function with important effects
on developmental processes, cognition, attention, motivation, reward, learning, and memory …

E‐cigarettes, which deliver vaporized nicotine, have dramatically risen in popularity in recent
years, despite many unanswered questions about safety, efficacy in reducing dependence …

Evidence in humans suggests a correlation between nicotine smoking and severe
respiratory symptoms with COVID-19 infection. In lung tissue, angiotensin-converting …

Since their introduction in the United States and Europe in 2007, electronic cigarettes (E-
Cigs) have become increasingly popular among smokers. Nicotine, a key component in both …

Perinatal exposure to prescription opioids pose a critical public health risk. Notably,
research has found significant neurodevelopmental and behavioral deficits between in utero …

Negative allosteric modulators, such as lynx1 and lynx2, directly interact with nicotinic
acetylcholine receptors (nAChRs). The nAChRs are integral to cholinergic signaling in the …

The landscape of worldwide tobacco use is changing, with a decrease in traditional smoking
and an exponential rise in electronic cigarette use. No new nicotine cessation …

Abstract Introduction Variation in CYP2A6, the primary enzyme responsible for nicotine
metabolism, is associated with nicotine dependence, cigarette consumption, and abstinence …

Ras/Raf/MEK/ERK (Ras-ERK) signaling has been demonstrated to play a role in the effects
of drugs of abuse such as cocaine and alcohol, but has not been extensively examined in …