Recently, in silico techniques have gained tremendous popularity in the field of small
molecule drug discovery. The computational jobs include not only hit generation, lead …

Nitrogen-containing heterocyclic rings are common structural components of marketed
drugs. Among these heterocycles, imidazole/fused imidazole rings are present in a wide …

Targeted therapy has emerged to be the cornerstone of advanced cancer treatment,
allowing for more selectivity and avoiding the common drug toxicity and resistance …

Aim: A fragment-based design and synthesis of three novel series of aminopyridone-linked
benzimidazoles as potential anticancer candidates with significant CDK9 inhibition was …

In these studies, we investigated the importance of isoindoline in pharmacological
evaluation, so we studied the crystal structure, packing, Hirshfeld analysis and …

A library of novel imidazole-1, 2, 3-triazole hybrids were designed and synthesized based
on the hybrid pharmacophore approach. Therefore, copper (I) catalyzed click reaction of …

A novel series of 2-phenylbenzimidazole scaffold was designed as dual tyrosine kinase
inhibitors based on targeted chemotherapy. All compounds were assessed for their …

Benzimidazole scaffolds have potent anticancer activity due to their structure similarity to
nucleoside. In addition, benzimidazoles could function as hydrogen donors or acceptors and …

The biofilm formation is still prevalent mechanism of developing the drug resistance in the
Pseudomonas aeruginosa, gram-negative bacteria, known for its major role in nosocomial …

In drug discovery process the identification of lead compounds by virtual screening is a
novel approach. From the literature it is understood that imidazoles and pyrimidines have …