Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Alzheimer's disease (AD) affects an estimated 44 million individuals worldwide, yet no
therapeutic intervention is available to stop the progression of the dementia …

The pathogenetic mechanisms underlying neuronal death and dysfunction in Alzheimer's
disease (AD) remain unclear. However, chronic neuroinflammation has been implicated in …

A systematic review was conducted to identify risk factors associated with the onset and
progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in the
elderly. Although the mechanisms underlying AD neurodegeneration are not fully …

This review analyzes the role of TNF-α and its increase in biological fluids in mild cognitive
impairment, and Alzheimer's disease (AD). The potential inhibition of TNF-α with …

Overnutrition and modern diets containing high proportions of saturated fat are among the
major factors contributing to a low-grade state of inflammation, hyperglycemia and …

This review details tumor necrosis factor alpha (TNF) biology and its role in sleep, and
describes how TNF medications influence sleep/wake activity. Substantial evidence from …

Alzheimer's disease (AD) and major depressive disorder (MDD) are highly prevalent
neuropsychiatric conditions with intriguing epidemiological overlaps. Depressed patients …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause of dementia. Accumulating experimental evidence shows the important …