Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis

MA Rocca, MP Amato, N De Stefano… - The Lancet …, 2015 - thelancet.com
In patients with multiple sclerosis (MS), grey matter damage is widespread and might
underlie many of the clinical symptoms, especially cognitive impairment. This relation …

Depressive symptoms, anxiety and cognitive impairment: emerging evidence in multiple sclerosis

M Margoni, P Preziosa, MA Rocca, M Filippi - Translational Psychiatry, 2023 - nature.com
Neuropsychiatric abnormalities may be broadly divided in two categories: disorders of
mood, affect, and behavior and abnormalities affecting cognition. Among these conditions …

Multiple sclerosis and cognition: synaptic failure and network dysfunction

M Di Filippo, E Portaccio, A Mancini… - Nature Reviews …, 2018 - nature.com
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …

Cognitive impairment in multiple sclerosis with regards to disease duration and clinical phenotypes

B Brochet, A Ruet - Frontiers in neurology, 2019 - frontiersin.org
The relationships between cognitive impairment that exist during the clinical course of
multiple sclerosis (MS) remain poorly described. The effect of disease duration has been …

White matter damage and cognitive impairment after traumatic brain injury

KM Kinnunen, R Greenwood, JH Powell, R Leech… - Brain, 2011 - academic.oup.com
White matter disruption is an important determinant of cognitive impairment after brain injury,
but conventional neuroimaging underestimates its extent. In contrast, diffusion tensor …

Cognitive impairment in multiple sclerosis–a review of current knowledge and recent research

T Grzegorski, J Losy - Reviews in the Neurosciences, 2017 - degruyter.com
Multiple sclerosis (MS) is a chronic, progressive disease of the central nervous system that is
characterised by inflammatory damage to the myelin sheath. Though often neglected …

Mind the gap: from neurons to networks to outcomes in multiple sclerosis

DT Chard, AAS Alahmadi, B Audoin… - Nature Reviews …, 2021 - nature.com
MRI studies have provided valuable insights into the structure and function of neural
networks, particularly in health and in classical neurodegenerative conditions such as …

Longitudinal assessment of chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning

S Deprez, F Amant, A Smeets, R Peeters… - Journal of Clinical …, 2012 - ascopubs.org
Purpose To uncover the neural substrate of cognitive impairment related to adjuvant
chemotherapy, we studied cerebral white matter (WM) integrity before and after …

Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis

S Batista, R Zivadinov, M Hoogs, N Bergsland… - Journal of …, 2012 - Springer
Abstract Information-processing speed (IPS) slowing is a primary cognitive deficit in multiple
sclerosis (MS). Basal ganglia, thalamus and neocortex are thought to have a key role for …

Information processing speed in multiple sclerosis: Past, present, and future

SL Costa, HM Genova, J DeLuca… - Multiple Sclerosis …, 2017 - journals.sagepub.com
Background: Information processing speed (IPS) is a prevalent cognitive impairment in
multiple sclerosis (MS). Objectives: This review aims to summarize the methods applied to …