With the financial requirements and high time associated with bringing a commercial drug to
the market, the application of computer-aided drug design has been recognized as a …

Abstract Inhibition of Tumor Necrosis Factor-alpha (TNF-alpha) represents a therapeutic
approach towards the management or treatment of various inflammatory diseases like …

Momordica charantia (bitter melon), a traditional medicinal plant, has been demonstrated to
have potential in managing diabetes, gastrointestinal problems, and infections. Among its …

In the vast majority of malignancies, the p53 tumor suppressor pathway is compromised. In
some cancer cells, high levels of MDM2 polyubiquitinate p53 and mark it for destruction …

The regulation of the p53 tumor suppressor pathway is critically dependent on the activity of
Murine Double Minute 2 (MDM2) and Murine Double Minute X (MDMX) proteins. In certain …

Antioxidant peptides (AOPs) are highly valued in food and pharmaceutical industries due to
their significant role in human function. This study introduces a novel approach to identifying …

Objectives While a fine balance in the pro-apoptotic and anti-apoptotic family members of
the B-cell lymphoma-2 (Bcl-2) protein family represents a normal signaling profile, a tilt in …

Cancer is a major global health issue that has a high mortality rate. p53, which functions as
a tumor suppressor, is critical in preventing tumor development by regulating the cell cycle …

Chlorogenic acid (CGA) is a dietary phenolic acid widely distributed in daily food and plants,
but its role in vascular dementia (VaD) is still unclear. Hence, this study aimed to investigate …

Malaria remains a significant public health challenge, with resistance to available drugs
necessitating the development of novel therapies targeting invasion-dependent proteins …