Diversification of Phage-Displayed Peptide Libraries with Noncanonical Amino Acid Mutagenesis and Chemical Modification

JT Hampton, WR Liu - Chemical reviews, 2024 - ACS Publications
Sitting on the interface between biologics and small molecules, peptides represent an
emerging class of therapeutics. Numerous techniques have been developed in the past 30 …

Comparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice uncover disease-relevant pathways

E Petrova, JM López-Gay, M Fahrner, F Leturcq… - Communications …, 2024 - nature.com
Netherton syndrome (NS) is a rare skin disease caused by loss-of-function mutations in the
serine peptidase inhibitor Kazal type 5 (SPINK5) gene. Disease severity and the lack of …

PAX6–WNK2 Axis Governs Corneal Epithelial Homeostasis

L Zhu, C Chen, S Wu, H Guo, L Li… - … & Visual Science, 2024 - iovs.arvojournals.org
Purpose: Limbal stem/progenitor cells (LSCs) continuously proliferate and differentiate to
replenish the corneal epithelium and play a vital role in corneal function and normal vision …

[HTML][HTML] Using NGS to Uncover the Corruption of a Peptide Phage Display Selection

DK Sell, B Bakhshinejad, AW Sinkjaer… - Current issues in …, 2024 - mdpi.com
Phage display has been widely used to identify peptides binding to a variety of biological
targets. In the current work, we planned to select novel peptides targeting CD4 through …