Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is
undeniably the most severe global health emergency since the 1918 Influenza outbreak …
undeniably the most severe global health emergency since the 1918 Influenza outbreak …
Investigating the transition of pre-symptomatic to symptomatic huntington's disease status based on omics data
Huntington's disease is a rare neurodegenerative disease caused by a cytosine–adenine–
guanine (CAG) trinucleotide expansion in the Huntingtin (HTT) gene. Although Huntington's …
guanine (CAG) trinucleotide expansion in the Huntingtin (HTT) gene. Although Huntington's …
Transcriptomic analysis reveals differentially expressed genes and key immune pathways in the spleen of the yak (Bos grunniens) at different growth stage
Q Mei, R Zheng, J Li, X Ma, L Wang, Y Wei, X Luo… - Gene, 2023 - Elsevier
Yak is one of the rare and unique cattle species on the Qinghai-Tibetan Plateau, which has
strong adaptability to the extreme environment of the plateau. The spleens are important …
strong adaptability to the extreme environment of the plateau. The spleens are important …
[HTML][HTML] PathIN: an integrated tool for the visualization of pathway interaction networks
G Minadakis, K Christodoulou, G Tsouloupas… - Computational and …, 2023 - Elsevier
PathIN is a web-service that provides an easy and flexible way for rapidly creating pathway-
based networks at several functional biological levels: genes, compounds and reactions …
based networks at several functional biological levels: genes, compounds and reactions …
Signaling pathways in the treatment of Alzheimer's disease with acupuncture: a narrative review
C Ke, S Shan, Y Tan, Y Cao, Z Xie… - Acupuncture in …, 2024 - journals.sagepub.com
Background: To date, there is no effective treatment for Alzheimer's disease (AD), a
progressive neurodegenerative disorder that is increasing in prevalence worldwide. The …
progressive neurodegenerative disorder that is increasing in prevalence worldwide. The …
Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action
Fibrotic diseases cover a spectrum of systemic and organ-specific maladies that affect a
large portion of the population, currently without cure. The shared characteristic these …
large portion of the population, currently without cure. The shared characteristic these …
Analyzing gene expression profiles from ataxia and spasticity phenotypes to reveal spastic ataxia related pathways
AC Kakouri, C Votsi, M Tomazou, G Minadakis… - International Journal of …, 2020 - mdpi.com
Spastic ataxia (SA) is a group of rare neurodegenerative diseases, characterized by mixed
features of generalized ataxia and spasticity. The pathogenetic mechanisms that drive the …
features of generalized ataxia and spasticity. The pathogenetic mechanisms that drive the …
Drug repurposing through a bioinformatics pipeline applied on IPF and other fibrotic diseases
Subject Fibrotic diseases cover a spectrum of systemic and organ-specific maladies that
affect a large portion of the population, currently without cure. The shared characteristic …
affect a large portion of the population, currently without cure. The shared characteristic …
[PDF][PDF] Network Signature Techniques for Drug Discovery in Pulmonary Fibrosis
E Karatzas - 2020 - di.uoa.gr
Fibrotic diseases cover a spectrum of systemic and organ specific diseases that affect a
large portion of the population, currently without cure. Idiopathic Pulmonary Fibrosis (IPF) is …
large portion of the population, currently without cure. Idiopathic Pulmonary Fibrosis (IPF) is …