Maintaining a healthy gut environment is a prerequisite for sustainable animal production.
The gut plays a key role in the digestion and absorption of nutrients and constitutes an initial …

Atopic dermatitis (AD) is a common chronic inflammatory skin disease that has increased in
prevalence over the last half century. A growing body of evidence suggests that there are a …

BACKGROUND: Atopic dermatitis (AD) is characterized by dry skin and a hyperactive
immune response to allergens, 2 cardinal features that are caused in part by epidermal …

Tricellulin is a tight junction protein localized in tricellular tight junctions (tTJs), the meeting
points of three cells, but also in bicellular tight junctions (bTJs). To investigate its specific …

The skin, the largest organ of the body, is an essential barrier that under homeostatic
conditions efficiently protects and/or minimizes damage from both environmental (eg …

Epithelial cell contacts consist of not only bicellular contacts but also tricellular contacts,
where the corners of three cells meet. At tricellular contacts, tight junctions (TJs) generate …

Although the existence of tight junction (TJ) structures (or a secondary epidermal barrier)
was postulated for a long time, the first description of TJ proteins in the epidermis (occludin …

The organization of metazoa is based on the formation of tissues and on tissue-typical
functions and these in turn are based on cell–cell connecting structures. In vertebrates, four …

Summary The neurofibromatosis type 2 (NF2) tumor suppressor, Merlin, is a FERM (Four
point one, Ezrin, Radixin, Moesin) domain-containing protein whose loss results in defective …

The occludin-like proteins belong to a family of tetraspan transmembrane proteins carrying a
marvel domain. The intrinsic function of the occludin family is not yet clear. Occludin is a …