Therapeutic strategies for thrombosis: new targets and approaches

N Mackman, W Bergmeier, GA Stouffer… - Nature reviews Drug …, 2020 - nature.com
Antiplatelet agents and anticoagulants are a mainstay for the prevention and treatment of
thrombosis. However, despite advances in antithrombotic therapy, a fundamental challenge …

The next step in the treatment of stroke

N Matei, J Camara, JH Zhang - Frontiers in Neurology, 2021 - frontiersin.org
Although many patients do not receive reperfusion therapy because of delayed presentation
and/or severity and location of infarct, new reperfusion approaches are expanding the …

Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs

T Burnett, P Mozgunov, P Pallmann, SS Villar… - BMC medicine, 2020 - Springer
Adaptive designs for clinical trials permit alterations to a study in response to accumulating
data in order to make trials more flexible, ethical, and efficient. These benefits are achieved …

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

RK Sinha, R Flynn, M Zaiken, K Paz… - Blood, The Journal …, 2019 - ashpublications.org
Soluble thrombomodulin plasma concentrations are elevated in steroid-resistant graft-
versus-host disease (GVHD), implying endothelial hypofunctioning for thrombomodulin …