Prevalence of colistin resistance in clinical isolates of Pseudomonas aeruginosa: a systematic review and meta-analysis

N Narimisa, A Keshtkar, L Dadgar-Zankbar… - Frontiers in …, 2024 - frontiersin.org
Objective The emergence of resistance to colistin, the last resort for treating severe
infections caused by Pseudomonas aeruginosa, poses a significant threat to public health …

Exploring synergistic and antagonistic interactions in phage-antibiotic combinations against ESKAPE pathogens

AJ Kunz Coyne, M Eshaya, C Bleick… - Microbiology …, 2024 - journals.asm.org
In the era of antimicrobial resistance, phage-antibiotic combinations offer a promising
therapeutic option, yet research on their synergy and antagonism is limited. This study aims …

Synergy of lytic phage pB23 and meropenem combination against carbapenem-resistant Acinetobacter baumannii

J Luo, M Liu, W Ai, X Zheng, S Liu… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Phage-antibiotic combination treatment is a novel noteworthy drug delivery method in anti-
infection. In the current study, we have isolated a new phage, pB23, against carbapenem …

Bacteriophage protein Dap1 regulates evasion of antiphage immunity and Pseudomonas aeruginosa virulence impacting phage therapy in mice

S Le, L Wei, J Wang, F Tian, Q Yang, J Zhao… - Nature …, 2024 - nature.com
Bacteriophages have evolved diverse strategies to overcome host defence mechanisms and
to redirect host metabolism to ensure successful propagation. Here we identify a phage …

Immunomodulator AS101 restores colistin susceptibility of clinical colistin-resistant Escherichia coli and Klebsiella pneumoniae in vitro and in vivo

H Liu, Y Zhang, Z Zhong, Y Gong, P Yu, Y Yang… - International Journal of …, 2024 - Elsevier
Objectives Colistin (COL) was once considered to be the last line of defence against
multidrug-resistant bacteria belonging to the family Enterobacteriaceae. Due to the misuse …

Isolation and preliminary characterization of a novel bacteriophage vB_KquU_φKuK6 that infects the multidrug-resistant pathogen Klebsiella quasipneumoniae

IP Miller, AG Laney, G Zahn, BJ Sheehan… - Frontiers in …, 2024 - frontiersin.org
Background Klebsiella quasipneumoniae (previously known as K. pneumoniae K6) strains
are among the multidrug-resistant hypervirulent bacterial pathogens. Phage therapy can …