The DNA sensor cGAS (cyclic GMP-AMP synthase) and its adaptor protein STING
(Stimulator of Interferon Genes) detect the presence of cytosolic DNA as a sign of infection or …

The emergence of immunotherapy has profoundly changed the treatment model for triple-
negative breast cancer (TNBC). But the heterogeneity of this disease resulted in significant …

The tumor microenvironment (TME) is a heterogeneous ecosystem containing cancer cells,
immune cells, stromal cells, cytokines, and chemokines which together govern tumor …

Unlike the intense research effort devoted to exploring the significance of heparanase in
cancer, very little attention was given to Hpa2, a close homolog of heparanase. Here, we …

Developing an intracellular delivery system is of key importance in the expansion of protein-
based therapeutics acting on cytosolic or nuclear targets. Recently, extracellular vesicles …

Therapy resistance is imposing a daunting challenge on effective clinical management of
breast cancer. Although the development of resistance to drugs is multifaceted …

Over the past decade, it has become clear that the stimulator of interferon genes (STING)
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …

Immunotherapeutic agents have revolutionized cancer treatment over the past decade.
However, most patients fail to respond to immunotherapy alone. A growing body of …

Cells in the tumor microenvironment (TME) of diffuse large B-cell lymphoma (DLBCL) show
enormous diversity and plasticity, with functions that can range from tumor inhibitory to tumor …

Single-cell RNA sequencing (scRNA-seq) has revealed important insights into the
heterogeneity of malignant cells. However, sample-specific genomic alterations often …