ALCAM/CD166: A pleiotropic mediator of cell adhesion, stemness and cancer progression

F Ferragut, VS Vachetta, MF Troncoso… - Cytokine & Growth …, 2021 - Elsevier
Abstract Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) is a glycoprotein
involved in homotypic and heterotypic cell adhesion. ALCAM can be proteolytically cleaved …

The universe of galectin-binding partners and their functions in health and disease

MF Troncoso, MT Elola, AG Blidner, L Sarrias… - Journal of Biological …, 2023 - ASBMB
Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in
diverse biological processes including tissue repair, adipogenesis, immune cell …

The cAMP/PKA/CREB and TGFβ/SMAD4 pathways regulate stemness and metastatic potential in colorectal cancer cells

T Fujishita, Y Kojima, R Kajino-Sakamoto… - Cancer Research, 2022 - AACR
Metastasis is responsible for the majority of deaths of patients with cancer. However,
mechanisms governing metastasis in colorectal cancer remain largely unknown. Here we …

Galectin targeted therapy in oncology: Current knowledge and perspectives

K Wdowiak, T Francuz, E Gallego-Colon… - International journal of …, 2018 - mdpi.com
The incidence and mortality of cancer have increased over the past decades. Significant
progress has been made in understanding the underpinnings of this disease and …

Endophilin-A3 and Galectin-8 control the clathrin-independent endocytosis of CD166

HF Renard, F Tyckaert, C Lo Giudice, T Hirsch… - Nature …, 2020 - nature.com
While several clathrin-independent endocytic processes have been described so far, their
biological relevance often remains elusive, especially in pathophysiological contexts such …

Galectin-9 as a potential modulator of lymphocyte adhesion to endothelium via binding to blood group H glycan

EM Rapoport, IM Ryzhov, EV Slivka, EY Korchagina… - Biomolecules, 2023 - mdpi.com
The recruitment of leukocytes from blood is one of the most important cellular processes in
response to tissue damage and inflammation. This multi-step process includes rolling …

Recent progress in surface plasmon resonance biosensors (2016 to mid-2018)

E Gorodkiewicz, Z Lukaszewski - Biosensors, 2018 - mdpi.com
More than 50 papers on surface plasmon resonance biosensors, published between 2016
and mid-2018, are reviewed. Papers concerning the determination of large particles such as …

[HTML][HTML] Dual knockdown of Galectin-8 and its glycosylated ligand, the activated leukocyte cell adhesion molecule (ALCAM/CD166), synergistically delays in vivo …

F Ferragut, AJ Cagnoni, LL Colombo… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Abstract Galectin-8 (Gal-8), a 'tandem-repeat'-type galectin, has been described as a
modulator of cellular functions including adhesion, spreading, growth arrest, apoptosis …

Galectin‐8 inhibition and functions in immune response and tumor biology

E Purić, UJ Nilsson, M Anderluh - Medicinal Research Reviews, 2024 - Wiley Online Library
Galectins are among organisms' most abundantly expressed lectins (carbohydrate‐binding
proteins) that specifically bind β‐galactosides. They act not only outside the cell, where they …

ALCAM is an entry factor for severe community acquired Pneumonia-associated Human adenovirus species B

Y Xie, H Mei, W Wang, X Li, P Hu, X Tian… - Nature …, 2024 - nature.com
Human adenovirus (HAdV) is a widely spread respiratory pathogen that can cause
infections in multiple tissues and organs. Previous studies have established an association …