This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …

As we enter the 21st century, a new era of nutrition in the prevention and treatment of
disease emerges. Clinical nutrition involves the integration of diet, genetics, environment …

Obesity is an important cause of morbidity and mortality in developed countries, and is also
becoming increasingly prevalent in the developing world. Although environmental factors …

Obesity and colorectal cancer (CRC) are among the leading diseases causing deaths in the
world, showing a complex multifactorial pathology. Obesity is considered a risk factor in …

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely
with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to …

Loos RJF, Bouchard C (Human Genomics Laboratory, Pennington Biomedical Research
Center, Baton Rouge, LA, USA). Obesity–is it a genetic disorder?(Review). J Intern Med …

Leptin is an important regulator of the mass of adipose tissue and of body weight; it operates
by inhibiting food intake and stimulating energy expenditure. Some polymorphic genes …

This is the tenth update of the human obesity gene map, incorporating published results up
to the end of October 2003 and continuing the previous format. Evidence from single‐gene …

Cardiovascular disease (CV) is the most common cause of premature mortality in patients
with rheumatoid arthritis (RA). This is the result of an accelerated atherosclerotic process …