Mitochondria are potent producers of cellular superoxide, from complexes I and III of the
electron transport chain, and mitochondrial superoxide production is a major cause of the …

The first member of the uncoupling protein (UCP) family, brown adipose tissue uncoupling
protein 1 (UCP1), was identified in 1976. Twenty years later, two closely related proteins …

Limb remote ischemic preconditioning (RIPC) is an effective means of protection against
ischemia/reperfusion (IR)–induced injury to multiple organs. Many studies are focused on …

Uncoupling protein‐2 (UCP2) belongs to the mitochondrial carrier family and has been
thought to be involved in suppressing mitochondrial ROS production through uncoupling …

The mitochondrial uncoupling proteins 2 and 3 (UCP2 and-3) are known to curtail oxidative
stress and participate in a wide array of cellular functions, including insulin secretion and the …

Metabolic energy expenditure negatively regulates energy balance. Metabolic and catabolic
pathways contribute to energy expenditure. Catabolic pathways split C-containing …

A physiological function of the original uncoupling protein, UCP1, is well established: UCP1
is the molecular background for nonshivering thermogenesis. The functions of the “novel” …

The uncoupling proteins (UCPs) are attracting an increased interest as potential therapeutic
targets in a number of important diseases. UCP2 is expressed in several tissues, but its …

Despite numerous therapies, cancer remains one of the leading causes of death worldwide
due to the lack of markers for early detection and response to treatment in many patients …

The c-Jun NH 2-terminal kinase (JNK) signaling pathway has been implicated in the
development of tumor necrosis factor (TNF)-dependent hepatitis. JNK may play a critical role …