Current methods for hyperpolarized [1‐13C]pyruvate MRI human studies
PEZ Larson, JML Bernard, JA Bankson… - Magnetic resonance …, 2024 - Wiley Online Library
Abstract MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can
measure processes such as localized metabolism that is altered in numerous cancers, liver …
measure processes such as localized metabolism that is altered in numerous cancers, liver …
[HTML][HTML] Quo Vadis Hyperpolarized 13C MRI?
Over the last two decades, hyperpolarized 13 C MRI has gained significance in both
preclinical and clinical studies, hereby relying on technologies like PHIP-SAH …
preclinical and clinical studies, hereby relying on technologies like PHIP-SAH …
A metabolite specific 3D stack-of-spirals bSSFP sequence for improved bicarbonate imaging in hyperpolarized [1-13C] Pyruvate MRI
Abstract 13 C-bicarbonate is a crucial measure of pyruvate oxidation and TCA cycle flux, but
is challenging to measure due to its relatively low concentration and thus will greatly benefit …
is challenging to measure due to its relatively low concentration and thus will greatly benefit …
Initial Experience on Hyperpolarized [1-13C]Pyruvate MRI Multicenter Reproducibility—Are Multicenter Trials Feasible?
Background: Magnetic resonance imaging (MRI) with hyperpolarized [1-13C] pyruvate
allows real-time and pathway specific clinical detection of otherwise unimageable in vivo …
allows real-time and pathway specific clinical detection of otherwise unimageable in vivo …
Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge
Background The heart has metabolic flexibility, which is influenced by fed/fasting states, and
pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM) …
pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM) …
Hyperpolarized 13C MR Spectroscopy Depicts in Vivo Effect of Exercise on Pyruvate Metabolism in Human Skeletal Muscle
Background Pyruvate dehydrogenase (PDH) and lactate dehydrogenase are essential for
adenosine triphosphate production in skeletal muscle. At the onset of exercise, oxidation of …
adenosine triphosphate production in skeletal muscle. At the onset of exercise, oxidation of …
Probing human heart TCA cycle metabolism and response to glucose load using hyperpolarized [2‐13C]pyruvate MRS
Introduction The healthy heart has remarkable metabolic flexibility that permits rapid
switching between mitochondrial glucose oxidation and fatty acid oxidation to generate ATP …
switching between mitochondrial glucose oxidation and fatty acid oxidation to generate ATP …
Dual‐phase imaging of cardiac metabolism using hyperpolarized pyruvate
Purpose Previous cardiac imaging studies using hyperpolarized (HP)[1‐13C] pyruvate were
acquired at end‐diastole (ED). Little is known about the interaction between cardiac cycle …
acquired at end‐diastole (ED). Little is known about the interaction between cardiac cycle …
A vendor‐neutral EPI sequence for hyperpolarized 13C MRI
T Blazey, A Shaw, C von Morze - Magnetic resonance in …, 2024 - Wiley Online Library
Purpose To develop a flexible, vendor‐neutral EPI sequence for hyperpolarized 13C
metabolic imaging. Methods An open‐source EPI sequence consisting of a metabolite …
metabolic imaging. Methods An open‐source EPI sequence consisting of a metabolite …
Dynamic relaxometry of hyperpolarized [1‐13C]pyruvate MRI in the human brain and kidneys
Purpose This study aimed to quantify T 2* T _2^ ∗ for hyperpolarized 1‐13C pyruvate and
metabolites in the healthy human brain and renal cell carcinoma (RCC) patients at 3 T …
metabolites in the healthy human brain and renal cell carcinoma (RCC) patients at 3 T …