New Insights into the Cooperativity and Dynamics of Dimeric Enzymes
KW Chen, TY Sun, YD Wu - Chemical Reviews, 2023 - ACS Publications
A survey of protein databases indicates that the majority of enzymes exist in oligomeric
forms, with about half of those found in the UniProt database being homodimeric …
forms, with about half of those found in the UniProt database being homodimeric …
[HTML][HTML] Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization
TR Guilarte, AN Rodichkin, JL McGlothan… - Pharmacology & …, 2022 - Elsevier
Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …
[HTML][HTML] The mutual and dynamic role of TSPO and ligands in their binding process: an example with PK-11195
Translocator protein (TSPO) is an 18 kDa transmembrane protein, localized primarily on the
outer mitochondrial membrane. It has been found to be involved in various physiological …
outer mitochondrial membrane. It has been found to be involved in various physiological …
CGMD platform: integrated web servers for the preparation, running, and analysis of coarse-grained molecular dynamics simulations
A Marchetto, Z Si Chaib, CA Rossi, R Ribeiro… - Molecules, 2020 - mdpi.com
Advances in coarse-grained molecular dynamics (CGMD) simulations have extended the
use of computational studies on biological macromolecules and their complexes, as well as …
use of computational studies on biological macromolecules and their complexes, as well as …
Mitochondrial targeting involving cholesterol-rich lipid rafts in the mechanism of action of the antitumor ether lipid and alkylphospholipid analog edelfosine
F Mollinedo, C Gajate - Pharmaceutics, 2021 - mdpi.com
The ether lipid edelfosine induces apoptosis selectively in tumor cells and is the prototypic
molecule of a family of synthetic antitumor compounds collectively known as …
molecule of a family of synthetic antitumor compounds collectively known as …
[HTML][HTML] Structure-Based Drug Design for TSPO: Challenges and Opportunities
The translocator protein 18 kDa (TSPO) is an evolutionarily conserved mitochondrial
transmembrane protein implicated in various neuropathologies and inflammatory conditions …
transmembrane protein implicated in various neuropathologies and inflammatory conditions …
The Interplay of Cholesterol and Ligand Binding in hTSPO from Classical Molecular Dynamics Simulations
The translocator protein (TSPO) is a 18kDa transmembrane protein, ubiquitously present in
human mitochondria. It is overexpressed in tumor cells and at the sites of …
human mitochondria. It is overexpressed in tumor cells and at the sites of …