A review of safety outcomes from clinical trials of baricitinib in rheumatology, dermatology and COVID-19

T Bieber, E Feist, AD Irvine, M Harigai, E Haladyj… - Advances in …, 2022 - Springer
Baricitinib is an oral, selective inhibitor of Janus kinase (JAK) 1/JAK2 that transiently and
reversibly inhibits many proinflammatory cytokines. This mechanism is a key mediator in a …

Current infections of the orofacial region: treatment, diagnosis, and epidemiology

E Tahmasebi, A Keshvad, M Alam, K Abbasi, S Rahimi… - Life, 2023 - mdpi.com
Undoubtedly, diagnosing and managing infections is one of the most challenging issues for
orofacial clinicians. As a result of the diversity of symptoms, complicated behavior, and …

Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): results from …

K Reich, HD Teixeira, M de Bruin-Weller, T Bieber… - The Lancet, 2021 - thelancet.com
Background Systemic therapies are typically combined with topical corticosteroids for the
management of moderate-to-severe atopic dermatitis. Upadacitinib is an oral Janus kinase …

Adverse events associated with JAK inhibitors in 126,815 reports from the WHO pharmacovigilance database

L Hoisnard, B Lebrun-Vignes, S Maury, M Mahevas… - Scientific Reports, 2022 - nature.com
Increasing number of Janus kinase (JAK) inhibitors have been approved for chronic
haematopoietic neoplasms and inflammatory/autoimmune diseases. We aimed to assess …

[HTML][HTML] A phase 3 randomized, multicenter, double-blind study to evaluate the safety of upadacitinib in combination with topical corticosteroids in adolescent and …

N Katoh, Y Ohya, H Murota, M Ikeda, X Hu, K Ikeda… - JAAD international, 2022 - Elsevier
Background Systemic atopic dermatitis treatments that have acceptable safety are needed.
Objective To evaluate the safety of the oral Janus kinase inhibitor upadacitinib in …

Flare management in atopic dermatitis: from definition to treatment

G Girolomoni, VM Busà - Therapeutic advances in chronic …, 2022 - journals.sagepub.com
Atopic dermatitis (AD) is a skin immune-mediated inflammatory disease with a chronic-
recurrent course. Acute exacerbations or flares are an integral part of the AD course and are …

[HTML][HTML] Enfrentamiento de las infecciones de piel en el adulto

R Flores, JL Villarroel, F Valenzuela - Revista médica clínica las condes, 2021 - Elsevier
En la actualidad, las infecciones de piel y partes blandas forman parte de un alto porcentaje
de las consultas en salud. Estas van desde infecciones leves, donde el manejo se realiza …

Herpes Simplex Virus 1 Can Bypass Impaired Epidermal Barriers upon Ex Vivo Infection of Skin from Atopic Dermatitis Patients

M Möckel, NC De La Cruz, M Rübsam, L Wirtz… - Journal of …, 2022 - Am Soc Microbiol
To infect its human host, herpes simplex virus 1 (HSV-1) must overcome the protective
barriers of skin and mucosa. Here, we addressed whether pathological skin conditions can …

Emerging concerns of atypical hand foot and mouth disease caused by recombinant Coxsackievirus A6 variants in Henan, China

S Chen, Y Chen, W Ji, F Wang, X Zhang… - Journal of Medical …, 2023 - Wiley Online Library
An increasing number of studies have reported that atypical hand, foot, and mouth disease
(HFMD) is becoming a new concern for children's health. At present, there is no official …

Stress reactivity, susceptibility to hypertension, and differential expression of genes in hypertensive compared to normotensive patients

D Oshchepkov, I Chadaeva, R Kozhemyakina… - International Journal of …, 2022 - mdpi.com
Although half of hypertensive patients have hypertensive parents, known hypertension-
related human loci identified by genome-wide analysis explain only 3% of hypertension …