Targeting of neuroinflammation by glibenclamide in Covid-19: old weapon from arsenal
GES Batiha, HM Al-Kuraishy, AI Al-Gareeb… - …, 2023 - Springer
Abstract In coronavirus disease 2019 (Covid-19) era, neuroinflammation may develop due
to neuronal tropism of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) …
to neuronal tropism of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) …
Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies
Monoamine oxidase enzyme is necessary for the management of brain functions. It
oxidatively metabolizes monoamines and produces ammonia, aldehyde and hydrogen …
oxidatively metabolizes monoamines and produces ammonia, aldehyde and hydrogen …
Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
ST Sudevan, JM Oh, MA Abdelgawad… - Scientific reports, 2022 - nature.com
The inhibitory action of fifteen benzyloxy ortho/para-substituted chalcones (B1-B15) was
evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO …
evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO …
Development of bromo-and fluoro-based α, β-unsaturated ketones as highly potent MAO-B inhibitors for the treatment of Parkinson's disease
This study evaluated the synthesis of a dual series of bromo (CHB1–CHB4)-and fluoro
(CHF1–CHF4)-based α, β-unsaturated ketones and their inhibitory activities against …
(CHF1–CHF4)-based α, β-unsaturated ketones and their inhibitory activities against …
Chalcone derivatives with a high potential as multifunctional antioxidant neuroprotectors
A Pérez-González, R Castañeda-Arriaga… - ACS …, 2022 - ACS Publications
A systematic, rational search for chalcone derivatives with multifunctional behavior has been
carried out, with the support of a computer-assisted protocol (CADMA-Chem). A total of 568 …
carried out, with the support of a computer-assisted protocol (CADMA-Chem). A total of 568 …
Halogenated coumarin–chalcones as multifunctional monoamine oxidase-B and butyrylcholinesterase inhibitors
A series of halogenated coumarin–chalcones were synthesized, characterized, and their
inhibitory activities against monoamine oxidases (MAOs), acetylcholinesterase (AChE) …
inhibitory activities against monoamine oxidases (MAOs), acetylcholinesterase (AChE) …
Development of isopropyl-tailed chalcones as a new class of selective MAO-B inhibitors for the treatment of Parkinson's disorder
S Kumar, JM Oh, MA Abdelgawad, MAS Abourehab… - ACS …, 2023 - ACS Publications
Thirteen isopropyl chalcones (CA1–CA13) were synthesized and evaluated for their
inhibitory activity against monoamine oxidase (MAO). All compounds inhibited MAO-B more …
inhibitory activity against monoamine oxidase (MAO). All compounds inhibited MAO-B more …
An ongoing journey of chalcone analogues as single and multi-target ligands in the field of Alzheimer's disease: A review with structural aspects
Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disorder with
progressive dementia and cognitive impairment. AD poses severe health challenge in …
progressive dementia and cognitive impairment. AD poses severe health challenge in …
Trimethoxylated halogenated chalcones as dual inhibitors of MAO-B and BACE-1 for the treatment of neurodegenerative disorders
VP Koyiparambath, JM Oh, A Khames… - Pharmaceutics, 2021 - mdpi.com
Six halogenated trimethoxy chalcone derivatives (CH1–CH6) were synthesized and
spectrally characterized. The compounds were further evaluated for their inhibitory potential …
spectrally characterized. The compounds were further evaluated for their inhibitory potential …
[HTML][HTML] A structural approach to investigate halogen substituted MAO-B inhibitors using QSAR modeling, molecular dynamics, and conceptual DFT analysis
Halogenated inhibitors showed robust, reversible, and selective monoamine oxidase-B
(MAO-B) inhibitory efficacy in candidates that were derived from them. Our team has …
(MAO-B) inhibitory efficacy in candidates that were derived from them. Our team has …