The biologically relevant coordination chemistry of iron and nitric oxide: electronic structure and reactivity

N Lehnert, E Kim, HT Dong, JB Harland… - Chemical …, 2021 - ACS Publications
Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

[HTML][HTML] Vascular nitric oxide: Beyond eNOS

Y Zhao, PM Vanhoutte, SWS Leung - Journal of pharmacological sciences, 2015 - Elsevier
As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of
cellular processes, including those involving vascular cells. This brief review summarizes …

[HTML][HTML] Functions and dysfunctions of nitric oxide in brain

P Picón-Pagès, J Garcia-Buendia, FJ Munoz - Biochimica et Biophysica …, 2019 - Elsevier
Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …

The noncanonical pathway for in vivo nitric oxide generation: the nitrate-nitrite-nitric oxide pathway

V Kapil, RS Khambata, DA Jones, K Rathod… - Pharmacological …, 2020 - Elsevier
In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

Oxidative stress in autoimmune rheumatic diseases

MJ Smallwood, A Nissim, AR Knight… - Free Radical Biology …, 2018 - Elsevier
The management of patients with autoimmune rheumatic diseases such as rheumatoid
arthritis (RA) remains a significant challenge. Often the rheumatologist is restricted to …

Dietary nitrate supplementation and exercise performance

AM Jones - Sports medicine, 2014 - Springer
Dietary nitrate is growing in popularity as a sports nutrition supplement. This article reviews
the evidence base for the potential of inorganic nitrate to enhance sports and exercise …

Dietary nitrate and physical performance

AM Jones, C Thompson, LJ Wylie… - Annual review of …, 2018 - annualreviews.org
Nitric oxide (NO) plays a plethora of important roles in the human body. Insufficient
production of NO (for example, during older age and in various disease conditions) can …

Reactive oxygen species in cardiovascular disease

K Sugamura, JF Keaney Jr - Free radical biology and medicine, 2011 - Elsevier
Based on the “free radical theory” of disease, researchers have been trying to elucidate the
role of oxidative stress from free radicals in cardiovascular disease. Considerable data …

Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation

K Cosby, KS Partovi, JH Crawford, RP Patel… - Nature medicine, 2003 - nature.com
Nitrite anions comprise the largest vascular storage pool of nitric oxide (NO), provided that
physiological mechanisms exist to reduce nitrite to NO. We evaluated the vasodilator …

Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol

PAL Pacher, A Nivorozhkin, C Szabó - Pharmacological reviews, 2006 - ASPET
The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the
clinical management of gout and conditions associated with hyperuricemia for several …