The thymus generates a lineage-committed subset of regulatory T-cells (Tregs), best
identified by the expression of the transcription factor FOXP3. The development of thymus …

Umbilical cord blood (UCB) is a source of primitive hematopoietic stem (HSC) and
progenitor cells, that served as an alternative to bone marrow (BM) for effective …

摘要1 型糖尿病是一类由自身免疫反应介导, 致使胰岛β 细胞损伤的慢性疾病.
传统的治疗方法并不能治愈该疾病. 针对1 型糖尿病发病机制, 抑制自身免疫, 恢复免疫平衡 …

Background The current paradigm for cord blood transplantation is that HLA matching and
immune suppression are strictly required to prevent graft versus host disease (GVHD) …

The process of dendritic cell differentiation is governed by a tightly controlled signaling
network regulated by cytokines and direct interaction between progenitor cells and bone …

Human CD34+ hematopoietic precursor cells cultured on delta-like ligand 1 expressing OP9
(OP9-DL1) stromal cells differentiate to T lineage cells. The nature of the T cells generated in …

Experimental autoimmune encephalomyelitis (EAE) is a CD4+ T cell-mediated inflammatory
demyelinating disease of the CNS that serves as a model for multiple sclerosis. Notch …

The Notch pathway represents a conserved signal transduction machinery that is
straightforward and based on a few elements (ligands, receptors, transducers). However, the …

The interaction between vascular endothelial cells (VECs) and osteoblasts (OBs) is the
focus of this recent research. Vascular endothelial cells secrete bone morphogenetic …

FOXP3-expressing regulatory T cells (Treg) are essential for the prevention of autoimmunity
and were shown to be reduced and/or dysfunctional in several autoimmune diseases …