Recently, it was proposed that there is a common mechanism behind the activity of
bactericidal antibiotics, involving the production of reactive oxygen species (ROS). However …

Reactive oxygen species (ROS) are well-known for playing a dual role as destructive and
constructive species. Indeed, ROS are engaged in many redox-governing activities of the …

Deeper understanding of antibiotic-induced physiological responses is critical to identifying
means for enhancing our current antibiotic arsenal. Bactericidal antibiotics with diverse …

Elevated levels of reactive oxygen species (ROS) reduce replication fork velocity by causing
dissociation of the TIMELESS-TIPIN complex from the replisome. Here, we show that ROS …

Antibiotic drug–target interactions, and their respective direct effects, are generally well
characterized. By contrast, the bacterial responses to antibiotic drug treatments that …

Highlights•Lethal antimicrobial stress triggers accumulation of reactive oxygen species
(ROS).•The stress-mediated ROS cascade and its effects are controlled in multiple ways.•At …

Many prokaryotic species generate hydrogen sulfide (H2S) in their natural environments.
However, the biochemistry and physiological role of this gas in nonsulfur bacteria remain …

Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nucleotides to
deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing …

Recent observations have suggested that classic antibiotics kill bacteria by stimulating the
formation of reactive oxygen species (ROS). If true, this notion might guide new strategies to …

Hydroxyurea is a well-established inhibitor of ribonucleotide reductase that has a long
history of scientific interest and clinical use for the treatment of neoplastic and non …