[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
[HTML][HTML] Structural understanding of SARS-CoV-2 virus entry to host cells
K Le, S Kannappan, T Kim, JH Lee, HR Lee… - Frontiers in Molecular …, 2023 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of …
coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of …
[HTML][HTML] Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients
Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-
2 monoclonal antibodies and vaccines currently used in clinical practice; broadly …
2 monoclonal antibodies and vaccines currently used in clinical practice; broadly …
[HTML][HTML] The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA. 2.86
Under pressure from neutralising antibodies induced by vaccination or infection the SARS-
CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all …
CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all …
[HTML][HTML] Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing …
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) marks the third novel β-
coronavirus to cause significant human mortality in the last two decades. Although vaccines …
coronavirus to cause significant human mortality in the last two decades. Although vaccines …
[HTML][HTML] A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection
Most neutralizing anti-SARS-CoV-2 monoclonal antibodies (mAbs) target the receptor
binding domain (RBD) of the spike (S) protein. Here, we characterize a panel of mAbs …
binding domain (RBD) of the spike (S) protein. Here, we characterize a panel of mAbs …
[HTML][HTML] A structure-function analysis shows SARS-CoV-2 BA. 2.86 balances antibody escape and ACE2 affinity
Summary BA. 2.86, a recently described sublineage of SARS-CoV-2 Omicron, contains
many mutations in the spike gene. It appears to have originated from BA. 2 and is distinct …
many mutations in the spike gene. It appears to have originated from BA. 2 and is distinct …
[HTML][HTML] Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes
The development of vaccines and therapeutics that are broadly effective against known and
emergent coronaviruses is an urgent priority. We screened the circulating B cell repertoires …
emergent coronaviruses is an urgent priority. We screened the circulating B cell repertoires …
[HTML][HTML] Exploring Factors Influencing Changes in Incidence and Severity of Multisystem Inflammatory Syndrome in Children
P Castaldo, G d'Alanno, GB Biserni, M Moratti, F Conti… - Pathogens, 2023 - mdpi.com
Multisystem inflammatory syndrome (MIS-C) is a rare condition associated with COVID-19
affecting children, characterized by severe and aberrant systemic inflammation leading to …
affecting children, characterized by severe and aberrant systemic inflammation leading to …
[HTML][HTML] Coarse-Grained Molecular Simulations and Ensemble-Based Mutational Profiling of Protein Stability in the Different Functional Forms of the SARS-CoV-2 …
G Verkhivker, M Alshahrani, G Gupta - International Journal of Molecular …, 2023 - mdpi.com
Evolutionary and functional studies have suggested that the emergence of Omicron variants
can be determined by multiple fitness tradeoffs including immune escape, binding affinity …
can be determined by multiple fitness tradeoffs including immune escape, binding affinity …