Self-nano-emulsifying drug-delivery systems: From the development to the current applications and challenges in oral drug delivery

AB Buya, A Beloqui, PB Memvanga, V Préat - Pharmaceutics, 2020 - mdpi.com
Approximately one third of newly discovered drug molecules show insufficient water
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …

50 years of oral lipid-based formulations: provenance, progress and future perspectives

OM Feeney, MF Crum, CL McEvoy, NL Trevaskis… - Advanced drug delivery …, 2016 - Elsevier
Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …

Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos

I Maji, S Mahajan, A Sriram, P Medtiya… - Journal of Controlled …, 2021 - Elsevier
A significant proportion of recently approved drug molecules possess poor aqueous
solubility which further restrains their desired bioavailability. Poor aqueous solubility of these …

Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs

X Zhang, H Xing, Y Zhao, Z Ma - Pharmaceutics, 2018 - mdpi.com
Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

Formulation approaches to pediatric oral drug delivery: benefits and limitations of current platforms

FL Lopez, TB Ernest, C Tuleu… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Most conventional drug delivery systems are not acceptable for pediatric
patients as they differ in their developmental status and dosing requirements from other …

Fundamental aspects of lipid-based excipients in lipid-based product development

D Nakmode, V Bhavana, P Thakor, J Madan, PK Singh… - Pharmaceutics, 2022 - mdpi.com
Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product
development. The use of lipids in designing formulations provides an opportunity to …

Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges

P Joyce, TJ Dening, TR Meola, HB Schultz… - Advanced drug delivery …, 2019 - Elsevier
Self-emulsifying drug delivery systems (SEDDS) offer potential for overcoming the inherent
slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a …

Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs

P Mohite, S Singh, A Pawar, A Sangale… - Frontiers in Drug …, 2023 - frontiersin.org
Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical
development, which is linked to their limited oral bioavailability and therapeutic efficacy. To …

[HTML][HTML] Review–an update on the use of oral phospholipid excipients

P van Hoogevest - European journal of pharmaceutical sciences, 2017 - Elsevier
The knowledge and experiences obtained with oral phospholipid excipients is increasing
continuously. Nevertheless the present number of oral products using these excipients as …

[HTML][HTML] Battle of the milky way: Lymphatic targeted drug delivery for pathogen eradication

A Taheri, KE Bremmell, P Joyce… - Journal of Controlled …, 2023 - Elsevier
Many viruses, bacteria, and parasites rely on the lymphatic system for survival, replication,
and dissemination. While conventional anti-infectives can combat infection-causing agents …