Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in
metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas …

Thiazole is one of the most important scaffolds in heterocyclic chemistry and drug design
and discovery. It is widely found in diverse pharmacologically active substances and in …

Acetylation is increasingly recognized as an important metabolic regulatory posttranslational
protein modification, yet the metabolic consequence of mitochondrial protein …

Background: Replacing SFAs with vegetable PUFAs has cardiometabolic benefits, but the
effects on liver fat are unknown. Increased dietary n-6 PUFAs have, however, also been …

A key and highly regulated enzyme that is required for the biosynthesis of monounsaturated
fatty acids is stearoyl-CoA desaturase (SCD), which catalyzes the D9-cis desaturation of a …

Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …

Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme catalyzing the synthesis of
monounsaturated fatty acids, mainly oleate (18: 1) and palmitoleate (16: 1). These represent …

Fatty acid metabolism is closely linked to the progression of gastric cancer (GC), a very
aggressive and life-threatening tumor. This study examines linked molecules, such as Sterol …

▪ Abstract Apart from being an important macronutrient, dietary fat has recently gained much
prominence for its role in regulating gene expression. Polyunsaturated fatty acids (PUFAs) …

The complex aetiology of type 2 diabetes makes effective screening, diagnosis and
prognosis a substantial challenge for the physician. The rapidly developing area of …